Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity

Receptor phosphorylation is thought to be tightly regulated because phosphorylated receptors initiate signaling cascades leading to cellular activation. The T cell antigen receptor (TCR) on the surface of T cells is phosphorylated by the kinase Lck and dephosphorylated by the phosphatase CD45 on mul...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Mukhopadhyay, H, Cordoba, S, Maini, P, Van Der Merwe, P, Dushek, O
Формат: Journal article
Хэл сонгох:English
Хэвлэсэн: Public Library of Science 2013