The role of CaMKII in diabetic heart dysfunction
Diabetes mellitus (DM) is an increasing epidemic that places a significant burden on health services worldwide. The incidence of heart failure (HF) is significantly higher in diabetic patients compared to non-diabetic patients. One underlying mechanism proposed for the link between DM and HF is acti...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2015
|
| _version_ | 1797062458122174464 |
|---|---|
| author | Daniels, L Bell, JR Delbridge, LMD McDonald, FJ Lamberts, RR Erickson, JR |
| author_facet | Daniels, L Bell, JR Delbridge, LMD McDonald, FJ Lamberts, RR Erickson, JR |
| author_sort | Daniels, L |
| collection | OXFORD |
| description | Diabetes mellitus (DM) is an increasing epidemic that places a significant burden on health services worldwide. The incidence of heart failure (HF) is significantly higher in diabetic patients compared to non-diabetic patients. One underlying mechanism proposed for the link between DM and HF is activation of calmodulin-dependent protein kinase (CaMKIIδ). CaMKIIδ mediates ion channel function and Ca2+ handling during excitation–contraction and excitation-transcription coupling in the myocardium. CaMKIIδ activity is up-regulated in the myocardium of diabetic patients and mouse models of diabetes, where it promotes pathological signaling that includes hypertrophy, fibrosis and apoptosis. Pharmacological inhibition and knockout models of CaMKIIδ have shown some promise of a potential therapeutic benefit of CaMKIIδ inhibition, with protection against cardiac hypertrophy and apoptosis reported. This review will highlight the pathological role of CaMKIIδ in diabetes and discuss CaMKIIδ as a therapeutic target in DM, and also the effects of exercise on CaMKIIδ. |
| first_indexed | 2024-03-06T20:45:50Z |
| format | Journal article |
| id | oxford-uuid:35d99106-1d3e-43f0-b5c5-9650c04534d8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:45:50Z |
| publishDate | 2015 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:35d99106-1d3e-43f0-b5c5-9650c04534d82022-03-26T13:34:25ZThe role of CaMKII in diabetic heart dysfunctionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:35d99106-1d3e-43f0-b5c5-9650c04534d8EnglishSymplectic Elements at OxfordSpringer Nature2015Daniels, LBell, JRDelbridge, LMDMcDonald, FJLamberts, RRErickson, JRDiabetes mellitus (DM) is an increasing epidemic that places a significant burden on health services worldwide. The incidence of heart failure (HF) is significantly higher in diabetic patients compared to non-diabetic patients. One underlying mechanism proposed for the link between DM and HF is activation of calmodulin-dependent protein kinase (CaMKIIδ). CaMKIIδ mediates ion channel function and Ca2+ handling during excitation–contraction and excitation-transcription coupling in the myocardium. CaMKIIδ activity is up-regulated in the myocardium of diabetic patients and mouse models of diabetes, where it promotes pathological signaling that includes hypertrophy, fibrosis and apoptosis. Pharmacological inhibition and knockout models of CaMKIIδ have shown some promise of a potential therapeutic benefit of CaMKIIδ inhibition, with protection against cardiac hypertrophy and apoptosis reported. This review will highlight the pathological role of CaMKIIδ in diabetes and discuss CaMKIIδ as a therapeutic target in DM, and also the effects of exercise on CaMKIIδ. |
| spellingShingle | Daniels, L Bell, JR Delbridge, LMD McDonald, FJ Lamberts, RR Erickson, JR The role of CaMKII in diabetic heart dysfunction |
| title | The role of CaMKII in diabetic heart dysfunction |
| title_full | The role of CaMKII in diabetic heart dysfunction |
| title_fullStr | The role of CaMKII in diabetic heart dysfunction |
| title_full_unstemmed | The role of CaMKII in diabetic heart dysfunction |
| title_short | The role of CaMKII in diabetic heart dysfunction |
| title_sort | role of camkii in diabetic heart dysfunction |
| work_keys_str_mv | AT danielsl theroleofcamkiiindiabeticheartdysfunction AT belljr theroleofcamkiiindiabeticheartdysfunction AT delbridgelmd theroleofcamkiiindiabeticheartdysfunction AT mcdonaldfj theroleofcamkiiindiabeticheartdysfunction AT lambertsrr theroleofcamkiiindiabeticheartdysfunction AT ericksonjr theroleofcamkiiindiabeticheartdysfunction AT danielsl roleofcamkiiindiabeticheartdysfunction AT belljr roleofcamkiiindiabeticheartdysfunction AT delbridgelmd roleofcamkiiindiabeticheartdysfunction AT mcdonaldfj roleofcamkiiindiabeticheartdysfunction AT lambertsrr roleofcamkiiindiabeticheartdysfunction AT ericksonjr roleofcamkiiindiabeticheartdysfunction |