Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.

Comparison of the crystal structures of the KcsA and MthK potassium channels suggests that the process of opening a K(+) channel involves pivoted bending of the inner pore-lining helices at a highly conserved glycine residue. This bending motion is proposed to splay the transmembrane domains outward...

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Bibliografiske detaljer
Main Authors:	Shang, L, Tucker, S
Format:	Journal article
Sprog:	English
Udgivet:	2008

Lignende værker

Identification of mutations in Kir5.1 which affect time-dependent activation of heteromeric Kir4.1/Kir5.1 potassium channels
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Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis.
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Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.
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Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.
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Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.
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Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1.
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Differential pH sensitivity of Kir4.1 and Kir4.2 and their modulation by heteropolymerisation with Kir5.1
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Autoantibodies to Potassium Channel KIR4.1 in Multiple Sclerosis
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EAST/SeSAME Syndrome and Beyond: The Spectrum of Kir4.1- and Kir5.1-Associated Channelopathies
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Functional characterisation of missense variations in the Kir4.1 potassium channel (KCNJ10) associated with seizure susceptibility.
af: Shang, L, et al.
Udgivet: (2005)

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.
af: Rapedius, M, et al.
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Potassium Channel KIR4.1-Specific Antibodies and Acquired Demyelinating Disease
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The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels.
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Unexpected Gating Behaviour of an Engineered Potassium Channel Kir
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pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia.
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Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.
af: Zubcevic, L, et al.
Udgivet: (2014)

Discovery, characterization and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.X and Kir7.1
af: Jerod S Denton
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Diverse functions of the inward-rectifying potassium channel Kir5.1 and its relationship with human diseases
af: Chaojie Zhang, et al.
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Astrocytic Kir4.1 potassium channels as a novel therapeutic target for epilepsy and mood disorders
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Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy.
af: Jarosławski, S, et al.
Udgivet: (2007)

Conformational rearrangements during PIP2 gating in Kir channels
af: Rapedius, M, et al.
Udgivet: (2007)

Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.
af: Rapedius, M, et al.
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The effect of high-dietary K+ (HK) on Kir4.1/Kir5.1 and ROMK in the distal convoluted tubule (DCT) is not affected by gender and Cl− content of the diet
af: Xin-Xin Meng, et al.
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Insights into the structural nature of the transition state in the Kir channel gating pathway.
af: Fowler, P, et al.
Udgivet: (2014)

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating
af: Bavro, V, et al.
Udgivet: (2012)

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.
af: Bavro, V, et al.
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KIR4.1 antibodies as biomarkers in multiple sclerosis
af: Marie eWunsch, et al.
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Crystal structure of the potassium channel KirBac1.1 in the closed state.
af: Kuo, A, et al.
Udgivet: (2003)

Heteromeric channel formation and Ca(2+)-free media reduce the toxic effect of the weaver Kir 3.2 allele.
af: Tucker, S, et al.
Udgivet: (1996)

Inhibitory effect of terfenadine on Kir2.1 and Kir2.3 channels
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Endocannabinoid regulation of inward rectifier potassium (Kir) channels
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Phosphoinositide Regulation of Inward Rectifier Potassium (Kir) Channels
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Characterization of a novel variant in KCNJ16, encoding Kir5.1 channel
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Astrocytic Kir4.1 channels and gap junctions account for spontaneous epileptic seizure.
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Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes
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Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16).
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Udgivet: (2011)

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.
af: Haider, S, et al.
Udgivet: (2007)

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
af: Reimann, F, et al.
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