Hypoxia inhibits MHC I expression and antigen presentation to escape immune surveillance

Hypoxia inhibits MHC I expression and antigen presentation to escape immune surveillance

Hypoxia is a common feature of solid tumors that has previously been linked to resistance to radiotherapy and chemotherapy, and more recently to immunotherapy. In particular, hypoxic tumors exclude T cells and inhibit their activity, suggesting that tumor cells acquire a mechanism to evade T cell re...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Estephan, H, Tailor, A, Parker, R, Kreamer, M, Papandreou, I, Campo, L, Easton, A, Moon, EJ, Denko, N, Ternette, N, Hammond, E, Giaccia, A
Format: Journal article
Sprache:English
Veröffentlicht: EMBO Press 2025

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