NANOG and NANOGNB protein alignments
A total of 147 NANOG and NANOGNB Refseq, Ensembl and blastp identified un-annotated protein sequences from mammals, reptiles, birds, and fish were downloaded and aligned using MAFFT before being visually inspected for conserved motifs. A series of six conserved motifs were identified. 1 - Alignment...
| Main Authors: | , |
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| Format: | Dataset |
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University of Oxford
2017
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| _version_ | 1797062524993011712 |
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| author | Dunwell, T Holland, P |
| author_facet | Dunwell, T Holland, P |
| author_sort | Dunwell, T |
| collection | OXFORD |
| description | A total of 147 NANOG and NANOGNB Refseq, Ensembl and blastp identified un-annotated protein sequences from mammals, reptiles, birds, and fish were downloaded and aligned using MAFFT before being visually inspected for conserved motifs. A series of six conserved motifs were identified.
1 - Alignment positions 505-519, this region of the NANOG protein is conserved between all species but not shared with NANOGNB.
2 - Alignment positions 524-530, this region of the NANOG and NANOGNB proteins is conserved across all species .
3 - Alignment positions 544-554, this region of NANOGNB is conserved only between reptile and bird NANOG proteins, and not with the mammal NANOG proteins.
4 - Alignment positions 555-581, this region is conserved between the NANOGNB proteins.
5 - Alignment positions 584-650, this region defines the homeodomain and is conserved across all NANOG and NANOGNB proteins.
6 - Alignment positions 684-690, this region of the NANOG protein is conserved between all species but not shared with NANOGNB. |
| first_indexed | 2024-03-06T20:46:45Z |
| format | Dataset |
| id | oxford-uuid:362b5563-4501-49df-a047-906e2cf82b28 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:46:45Z |
| publishDate | 2017 |
| publisher | University of Oxford |
| record_format | dspace |
| spelling | oxford-uuid:362b5563-4501-49df-a047-906e2cf82b282022-03-26T13:36:13ZNANOG and NANOGNB protein alignmentsDatasethttp://purl.org/coar/resource_type/c_ddb1uuid:362b5563-4501-49df-a047-906e2cf82b28ORA DepositUniversity of Oxford2017Dunwell, THolland, PA total of 147 NANOG and NANOGNB Refseq, Ensembl and blastp identified un-annotated protein sequences from mammals, reptiles, birds, and fish were downloaded and aligned using MAFFT before being visually inspected for conserved motifs. A series of six conserved motifs were identified. 1 - Alignment positions 505-519, this region of the NANOG protein is conserved between all species but not shared with NANOGNB. 2 - Alignment positions 524-530, this region of the NANOG and NANOGNB proteins is conserved across all species . 3 - Alignment positions 544-554, this region of NANOGNB is conserved only between reptile and bird NANOG proteins, and not with the mammal NANOG proteins. 4 - Alignment positions 555-581, this region is conserved between the NANOGNB proteins. 5 - Alignment positions 584-650, this region defines the homeodomain and is conserved across all NANOG and NANOGNB proteins. 6 - Alignment positions 684-690, this region of the NANOG protein is conserved between all species but not shared with NANOGNB. |
| spellingShingle | Dunwell, T Holland, P NANOG and NANOGNB protein alignments |
| title | NANOG and NANOGNB protein alignments |
| title_full | NANOG and NANOGNB protein alignments |
| title_fullStr | NANOG and NANOGNB protein alignments |
| title_full_unstemmed | NANOG and NANOGNB protein alignments |
| title_short | NANOG and NANOGNB protein alignments |
| title_sort | nanog and nanognb protein alignments |
| work_keys_str_mv | AT dunwellt nanogandnanognbproteinalignments AT hollandp nanogandnanognbproteinalignments |