Antimalarial mass drug administration: ethical considerations
Falciparum malaria is a major cause of death and illness in tropical countries, particularly in childhood. In endemic countries, a significant proportion of the community is infected with malaria asymptomatically. One promising way to eliminate malaria is to give the entire population malaria treatm...
| Glavni autori: | , |
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| Format: | Journal article |
| Jezik: | English |
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Oxford University Press
2016
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| _version_ | 1826308340263682048 |
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| author | Cheah, PY White, NJ |
| author_facet | Cheah, PY White, NJ |
| author_sort | Cheah, PY |
| collection | OXFORD |
| description | Falciparum malaria is a major cause of death and illness in tropical countries, particularly in childhood. In endemic countries, a significant proportion of the community is infected with malaria asymptomatically. One promising way to eliminate malaria is to give the entire population malaria treatment. This is called mass drug administration (MDA) and it raises a number of ethical issues, as possible long-term benefits are uncertain. The effectiveness of MDA is critically dependent on level of participation, so the promised benefits to the community can be annulled by non-participation of a small number of individuals. These potential benefits range a wide spectrum, from the permanent elimination of malaria (success) to a transient reduction in the prevalence of infection and the incidence of illness (failure). The drawbacks of MDA are: inconvenience, potential toxicity, loss of confidence in the elimination campaign, possible drug resistance (though highly unlikely), and the potential for a rebound of malaria illness (if immunity is lost and malaria is reintroduced later). Other ethical issues are related to balancing individual and public health interests, and potentially limiting individual autonomy by making MDA compulsory. |
| first_indexed | 2024-03-07T07:18:05Z |
| format | Journal article |
| id | oxford-uuid:362c1cee-e0e8-445e-8bf9-1791cbb081ed |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:18:05Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:362c1cee-e0e8-445e-8bf9-1791cbb081ed2022-09-08T11:16:07ZAntimalarial mass drug administration: ethical considerationsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:362c1cee-e0e8-445e-8bf9-1791cbb081edEnglishSymplectic Elements at OxfordOxford University Press2016Cheah, PYWhite, NJFalciparum malaria is a major cause of death and illness in tropical countries, particularly in childhood. In endemic countries, a significant proportion of the community is infected with malaria asymptomatically. One promising way to eliminate malaria is to give the entire population malaria treatment. This is called mass drug administration (MDA) and it raises a number of ethical issues, as possible long-term benefits are uncertain. The effectiveness of MDA is critically dependent on level of participation, so the promised benefits to the community can be annulled by non-participation of a small number of individuals. These potential benefits range a wide spectrum, from the permanent elimination of malaria (success) to a transient reduction in the prevalence of infection and the incidence of illness (failure). The drawbacks of MDA are: inconvenience, potential toxicity, loss of confidence in the elimination campaign, possible drug resistance (though highly unlikely), and the potential for a rebound of malaria illness (if immunity is lost and malaria is reintroduced later). Other ethical issues are related to balancing individual and public health interests, and potentially limiting individual autonomy by making MDA compulsory. |
| spellingShingle | Cheah, PY White, NJ Antimalarial mass drug administration: ethical considerations |
| title | Antimalarial mass drug administration: ethical considerations |
| title_full | Antimalarial mass drug administration: ethical considerations |
| title_fullStr | Antimalarial mass drug administration: ethical considerations |
| title_full_unstemmed | Antimalarial mass drug administration: ethical considerations |
| title_short | Antimalarial mass drug administration: ethical considerations |
| title_sort | antimalarial mass drug administration ethical considerations |
| work_keys_str_mv | AT cheahpy antimalarialmassdrugadministrationethicalconsiderations AT whitenj antimalarialmassdrugadministrationethicalconsiderations |