Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling

Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling

Zika virus (ZIKV) is a major public health concern in the Americas. We report that ZIKV infection and RNA extracted from ZIKV infected cells potently activated the induction of type I interferons (IFNs). This effect was fully dependent on the mitochondrial antiviral signalling protein (MAVS), implic...

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Bibliographic Details
Main Authors:	Hertzog, J, Dias, A, Rigby, R, Donald, C, Mayer, A, Sezgin, E, Song, C, Jin, B, Hublitz, P, Eggeling, C, Kohl, A, Rehwinkel, J
Format:	Journal article
Published:	Wiley 2018

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