An enzymatic approach to the desymmetrization of disubstituted pyrrolines.

The enzymatic desymmetrization of 2,2- and 2,5-disubstituted pyrroline compounds is reported in a procedure which gives access to both enantiomers in excellent enantiomeric excess and good yield. The enzyme reaction precursors are formed easily from two readily available substituted pyrroles using b...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Donohoe, T, Rigby, C, Thomas, R, Nieuwenhuys, W, Bhatti, F, Cowley, A, Bhalay, G, Linney, I
التنسيق: Journal article
اللغة:English
منشور في: 2006

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