The evolutionary landscape of alternative splicing in vertebrate species.
How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity bet...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797062537761521664 |
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| author | Barbosa-Morais, N Irimia, M Pan, Q Xiong, H Gueroussov, S Lee, L Slobodeniuc, V Kutter, C Watt, S Colak, R Kim, T Misquitta-Ali, C Wilson, MD Kim, P Odom, D Frey, B Blencowe, B |
| author_facet | Barbosa-Morais, N Irimia, M Pan, Q Xiong, H Gueroussov, S Lee, L Slobodeniuc, V Kutter, C Watt, S Colak, R Kim, T Misquitta-Ali, C Wilson, MD Kim, P Odom, D Frey, B Blencowe, B |
| author_sort | Barbosa-Morais, N |
| collection | OXFORD |
| description | How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of physiologically equivalent organs diverged such that they are more strongly related to the identity of a species than they are to organ type. Most vertebrate species-specific splicing patterns are cis-directed. However, a subset of pronounced splicing changes are predicted to remodel protein interactions involving trans-acting regulators. These events likely further contributed to the diversification of splicing and other transcriptomic changes that underlie phenotypic differences among vertebrate species. |
| first_indexed | 2024-03-06T20:46:56Z |
| format | Journal article |
| id | oxford-uuid:36392a8e-ba5f-40f4-86eb-430be991b375 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:46:56Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:36392a8e-ba5f-40f4-86eb-430be991b3752022-03-26T13:36:31ZThe evolutionary landscape of alternative splicing in vertebrate species.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:36392a8e-ba5f-40f4-86eb-430be991b375EnglishSymplectic Elements at Oxford2012Barbosa-Morais, NIrimia, MPan, QXiong, HGueroussov, SLee, LSlobodeniuc, VKutter, CWatt, SColak, RKim, TMisquitta-Ali, CWilson, MDKim, POdom, DFrey, BBlencowe, BHow species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of physiologically equivalent organs diverged such that they are more strongly related to the identity of a species than they are to organ type. Most vertebrate species-specific splicing patterns are cis-directed. However, a subset of pronounced splicing changes are predicted to remodel protein interactions involving trans-acting regulators. These events likely further contributed to the diversification of splicing and other transcriptomic changes that underlie phenotypic differences among vertebrate species. |
| spellingShingle | Barbosa-Morais, N Irimia, M Pan, Q Xiong, H Gueroussov, S Lee, L Slobodeniuc, V Kutter, C Watt, S Colak, R Kim, T Misquitta-Ali, C Wilson, MD Kim, P Odom, D Frey, B Blencowe, B The evolutionary landscape of alternative splicing in vertebrate species. |
| title | The evolutionary landscape of alternative splicing in vertebrate species. |
| title_full | The evolutionary landscape of alternative splicing in vertebrate species. |
| title_fullStr | The evolutionary landscape of alternative splicing in vertebrate species. |
| title_full_unstemmed | The evolutionary landscape of alternative splicing in vertebrate species. |
| title_short | The evolutionary landscape of alternative splicing in vertebrate species. |
| title_sort | evolutionary landscape of alternative splicing in vertebrate species |
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