Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study
<p><strong>Objective</strong> To determine if migraine with aura is associated with neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well as imaging of human pain conditions.</p> <p><strong>Methods</str...
| Հիմնական հեղինակներ: | , , , , , , , , , , , , |
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| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
American Academy of Neurology
2019
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| _version_ | 1826266967271538688 |
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| author | Albrecht, D Mainero, C Ichijo, E Ward, N Granziera, C Zürcher, N Akeju, O Bonnier, G Price, J Hooker, J Napadow, V Loggia, M Hadjikhani, N |
| author_facet | Albrecht, D Mainero, C Ichijo, E Ward, N Granziera, C Zürcher, N Akeju, O Bonnier, G Price, J Hooker, J Napadow, V Loggia, M Hadjikhani, N |
| author_sort | Albrecht, D |
| collection | OXFORD |
| description | <p><strong>Objective</strong> To determine if migraine with aura is associated with neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well as imaging of human pain conditions.</p> <p><strong>Methods</strong> Thirteen migraineurs with aura and 16 healthy controls received integrated PET/MRI brain scans with [<sup>11</sup>C]PBR28, a radioligand that binds to the 18 kDa translocator protein, a marker of glial activation. Standardized uptake value ratio (SUVR) was compared between groups, and regressed against clinical variables, using region of interest and whole-brain voxelwise analyses.</p> <p><strong>Results</strong> Compared to healthy controls, migraineurs demonstrated SUVR elevations in nociceptive processing areas (e.g., thalamus and primary/secondary somatosensory and insular cortices) as well as in areas previously shown to be involved in CSD generation (visual cortex). SUVR levels in frontoinsular cortex, primary/secondary somatosensory cortices, and basal ganglia were correlated with frequency of migraine attacks.</p> <p><strong>Conclusions</strong> These findings demonstrate that migraine with aura is associated with neuroimmune activation/neuroinflammation, and support a possible link between CSD and glial activation, previously observed in animals.</p> |
| first_indexed | 2024-03-06T20:46:59Z |
| format | Journal article |
| id | oxford-uuid:363b8c69-26b5-4ba8-9136-bbcce3d33f9e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:46:59Z |
| publishDate | 2019 |
| publisher | American Academy of Neurology |
| record_format | dspace |
| spelling | oxford-uuid:363b8c69-26b5-4ba8-9136-bbcce3d33f9e2022-03-26T13:36:39ZImaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:363b8c69-26b5-4ba8-9136-bbcce3d33f9eEnglishSymplectic Elements at OxfordAmerican Academy of Neurology2019Albrecht, DMainero, CIchijo, EWard, NGranziera, CZürcher, NAkeju, OBonnier, GPrice, JHooker, JNapadow, VLoggia, MHadjikhani, N<p><strong>Objective</strong> To determine if migraine with aura is associated with neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well as imaging of human pain conditions.</p> <p><strong>Methods</strong> Thirteen migraineurs with aura and 16 healthy controls received integrated PET/MRI brain scans with [<sup>11</sup>C]PBR28, a radioligand that binds to the 18 kDa translocator protein, a marker of glial activation. Standardized uptake value ratio (SUVR) was compared between groups, and regressed against clinical variables, using region of interest and whole-brain voxelwise analyses.</p> <p><strong>Results</strong> Compared to healthy controls, migraineurs demonstrated SUVR elevations in nociceptive processing areas (e.g., thalamus and primary/secondary somatosensory and insular cortices) as well as in areas previously shown to be involved in CSD generation (visual cortex). SUVR levels in frontoinsular cortex, primary/secondary somatosensory cortices, and basal ganglia were correlated with frequency of migraine attacks.</p> <p><strong>Conclusions</strong> These findings demonstrate that migraine with aura is associated with neuroimmune activation/neuroinflammation, and support a possible link between CSD and glial activation, previously observed in animals.</p> |
| spellingShingle | Albrecht, D Mainero, C Ichijo, E Ward, N Granziera, C Zürcher, N Akeju, O Bonnier, G Price, J Hooker, J Napadow, V Loggia, M Hadjikhani, N Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study |
| title | Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study |
| title_full | Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study |
| title_fullStr | Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study |
| title_full_unstemmed | Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study |
| title_short | Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study |
| title_sort | imaging of neuroinflammation in migraine with aura a 11c pbr28 pet mri study |
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