Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria.
In Thailand, approximately 8% of patients treated for vivax malaria are found subsequently to have coinfection with Plasmodium falciparum. A P. falciparum histidine rich protein 2 (PfHRP-2) dipstick test was evaluated as a predictor of mixed infections with subpatent P. falciparum in a prospective s...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1826266996197556224 |
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| author | Mayxay, M Pukritrayakamee, S Chotivanich, K Imwong, M Looareesuwan, S White, N |
| author_facet | Mayxay, M Pukritrayakamee, S Chotivanich, K Imwong, M Looareesuwan, S White, N |
| author_sort | Mayxay, M |
| collection | OXFORD |
| description | In Thailand, approximately 8% of patients treated for vivax malaria are found subsequently to have coinfection with Plasmodium falciparum. A P. falciparum histidine rich protein 2 (PfHRP-2) dipstick test was evaluated as a predictor of mixed infections with subpatent P. falciparum in a prospective study of 238 patients admitted to the hospital with acute vivax malaria. Of these, 23 (10%) had subsequent development of falciparum malaria without reexposure. Patients with cryptic P. falciparum infection had a significantly lower mean (standard deviation) hematocrit than those with P. vivax alone: 29.6 (7.6%) versus 37.2 (6.4%) (P < 0.0001). Using microscopic appearance of P. falciparum after the start of treatment as the reference standard, the PfHRP-2 test was 74% sensitive and 99% specific in predicting mixed infections with subpatent P. falciparum parasitemia at presentation. The PfHRP-2 dipstick test may be a useful adjunct to microscopy in areas where mixed infections are common. |
| first_indexed | 2024-03-06T20:47:25Z |
| format | Journal article |
| id | oxford-uuid:36612ee5-31f3-4cef-b60c-b343aa07c7db |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:47:25Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:36612ee5-31f3-4cef-b60c-b343aa07c7db2022-03-26T13:37:34ZIdentification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:36612ee5-31f3-4cef-b60c-b343aa07c7dbEnglishSymplectic Elements at Oxford2001Mayxay, MPukritrayakamee, SChotivanich, KImwong, MLooareesuwan, SWhite, NIn Thailand, approximately 8% of patients treated for vivax malaria are found subsequently to have coinfection with Plasmodium falciparum. A P. falciparum histidine rich protein 2 (PfHRP-2) dipstick test was evaluated as a predictor of mixed infections with subpatent P. falciparum in a prospective study of 238 patients admitted to the hospital with acute vivax malaria. Of these, 23 (10%) had subsequent development of falciparum malaria without reexposure. Patients with cryptic P. falciparum infection had a significantly lower mean (standard deviation) hematocrit than those with P. vivax alone: 29.6 (7.6%) versus 37.2 (6.4%) (P < 0.0001). Using microscopic appearance of P. falciparum after the start of treatment as the reference standard, the PfHRP-2 test was 74% sensitive and 99% specific in predicting mixed infections with subpatent P. falciparum parasitemia at presentation. The PfHRP-2 dipstick test may be a useful adjunct to microscopy in areas where mixed infections are common. |
| spellingShingle | Mayxay, M Pukritrayakamee, S Chotivanich, K Imwong, M Looareesuwan, S White, N Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. |
| title | Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. |
| title_full | Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. |
| title_fullStr | Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. |
| title_full_unstemmed | Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. |
| title_short | Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. |
| title_sort | identification of cryptic coinfection with plasmodium falciparum in patients presenting with vivax malaria |
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