Design and assembly of double-crossover linear arrays of micrometre length using rolling circle replication
We demonstrate the use of rolling circle replication to template linear DNA arrays whose sizes bridge the gap between nanometre-scale self-assembly and top-down lithographic fabrication. Using rolling circle replication we have produced an oligonucleotide containing several hundred repeats of a shor...
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| Format: | Journal article |
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IOP Science
2005
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| _version_ | 1797062579429834752 |
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| author | Lubrich, D Bath, J Turberfield, A |
| author_facet | Lubrich, D Bath, J Turberfield, A |
| author_sort | Lubrich, D |
| collection | OXFORD |
| description | We demonstrate the use of rolling circle replication to template linear DNA arrays whose sizes bridge the gap between nanometre-scale self-assembly and top-down lithographic fabrication. Using rolling circle replication we have produced an oligonucleotide containing several hundred repeats of a short sequence motif. On this template we have constructed, by self-assembly, an array consisting of two parallel duplexes periodically linked by antiparallel Holliday junctions. We have observed arrays up to 10 νm in length by atomic force microscopy. © 2005 IOP Publishing Ltd. |
| first_indexed | 2024-03-06T20:47:32Z |
| format | Journal article |
| id | oxford-uuid:366c8649-4415-483e-bb6a-c1d3124c4ec9 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:47:32Z |
| publishDate | 2005 |
| publisher | IOP Science |
| record_format | dspace |
| spelling | oxford-uuid:366c8649-4415-483e-bb6a-c1d3124c4ec92022-03-26T13:37:47ZDesign and assembly of double-crossover linear arrays of micrometre length using rolling circle replicationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:366c8649-4415-483e-bb6a-c1d3124c4ec9Symplectic Elements at OxfordIOP Science2005Lubrich, DBath, JTurberfield, AWe demonstrate the use of rolling circle replication to template linear DNA arrays whose sizes bridge the gap between nanometre-scale self-assembly and top-down lithographic fabrication. Using rolling circle replication we have produced an oligonucleotide containing several hundred repeats of a short sequence motif. On this template we have constructed, by self-assembly, an array consisting of two parallel duplexes periodically linked by antiparallel Holliday junctions. We have observed arrays up to 10 νm in length by atomic force microscopy. © 2005 IOP Publishing Ltd. |
| spellingShingle | Lubrich, D Bath, J Turberfield, A Design and assembly of double-crossover linear arrays of micrometre length using rolling circle replication |
| title | Design and assembly of double-crossover linear arrays of micrometre length using rolling circle replication |
| title_full | Design and assembly of double-crossover linear arrays of micrometre length using rolling circle replication |
| title_fullStr | Design and assembly of double-crossover linear arrays of micrometre length using rolling circle replication |
| title_full_unstemmed | Design and assembly of double-crossover linear arrays of micrometre length using rolling circle replication |
| title_short | Design and assembly of double-crossover linear arrays of micrometre length using rolling circle replication |
| title_sort | design and assembly of double crossover linear arrays of micrometre length using rolling circle replication |
| work_keys_str_mv | AT lubrichd designandassemblyofdoublecrossoverlineararraysofmicrometrelengthusingrollingcirclereplication AT bathj designandassemblyofdoublecrossoverlineararraysofmicrometrelengthusingrollingcirclereplication AT turberfielda designandassemblyofdoublecrossoverlineararraysofmicrometrelengthusingrollingcirclereplication |