In vivo 'purging' of residual disease in CLL with Campath-1H.
We assessed the role of human CD52 antibody (Campath-1H) in six patients with chronic lymphocytic leukaemia (CLL) treated to maximal response with purine analogues (fludarabine/deoxycoformycin) in whom persistent leukaemic infiltration of blood and bone marrow had precluded autologous stem cell tran...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1797062609796595712 |
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| author | Dyer, M Kelsey, S Mackay, H Emmett, E Thornton, P Hale, G Waldmann, H Newland, A Catovsky, D |
| author_facet | Dyer, M Kelsey, S Mackay, H Emmett, E Thornton, P Hale, G Waldmann, H Newland, A Catovsky, D |
| author_sort | Dyer, M |
| collection | OXFORD |
| description | We assessed the role of human CD52 antibody (Campath-1H) in six patients with chronic lymphocytic leukaemia (CLL) treated to maximal response with purine analogues (fludarabine/deoxycoformycin) in whom persistent leukaemic infiltration of blood and bone marrow had precluded autologous stem cell transplantation. Five patients achieved haematological and histological complete remission following Campath-1H and one had minimal focal residual CLL in a trephine biopsy. Autologous transplantation was performed in two patients without complications and with rapid haemopoietic engraftment. Treatment with Campath-1H may be of value in eradicating residual disease in CLL and may facilitate high-dose therapy in young patients. |
| first_indexed | 2024-03-06T20:47:59Z |
| format | Journal article |
| id | oxford-uuid:3692810e-f0a3-415d-9b26-86c73d2521ab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:47:59Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:3692810e-f0a3-415d-9b26-86c73d2521ab2022-03-26T13:38:49ZIn vivo 'purging' of residual disease in CLL with Campath-1H.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3692810e-f0a3-415d-9b26-86c73d2521abEnglishSymplectic Elements at Oxford1997Dyer, MKelsey, SMackay, HEmmett, EThornton, PHale, GWaldmann, HNewland, ACatovsky, DWe assessed the role of human CD52 antibody (Campath-1H) in six patients with chronic lymphocytic leukaemia (CLL) treated to maximal response with purine analogues (fludarabine/deoxycoformycin) in whom persistent leukaemic infiltration of blood and bone marrow had precluded autologous stem cell transplantation. Five patients achieved haematological and histological complete remission following Campath-1H and one had minimal focal residual CLL in a trephine biopsy. Autologous transplantation was performed in two patients without complications and with rapid haemopoietic engraftment. Treatment with Campath-1H may be of value in eradicating residual disease in CLL and may facilitate high-dose therapy in young patients. |
| spellingShingle | Dyer, M Kelsey, S Mackay, H Emmett, E Thornton, P Hale, G Waldmann, H Newland, A Catovsky, D In vivo 'purging' of residual disease in CLL with Campath-1H. |
| title | In vivo 'purging' of residual disease in CLL with Campath-1H. |
| title_full | In vivo 'purging' of residual disease in CLL with Campath-1H. |
| title_fullStr | In vivo 'purging' of residual disease in CLL with Campath-1H. |
| title_full_unstemmed | In vivo 'purging' of residual disease in CLL with Campath-1H. |
| title_short | In vivo 'purging' of residual disease in CLL with Campath-1H. |
| title_sort | in vivo purging of residual disease in cll with campath 1h |
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