E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.
Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-deri...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797062635201495040 |
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| author | Siddiqui, K Laffont, S Powrie, F |
| author_facet | Siddiqui, K Laffont, S Powrie, F |
| author_sort | Siddiqui, K |
| collection | OXFORD |
| description | Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-derived inflammatory DCs that express E-cadherin, the receptor for CD103, promote intestinal inflammation. E-cadherin(+) DCs accumulated in the inflamed mesenteric lymph nodes and colon, had high expression of toll-like receptors, and produced colitogenic cytokines, such as IL-6 and IL-23, after activation. Importantly, adoptive transfer of E-cadherin(+) DCs into T cell-restored immunodeficient hosts increased Th17 cell responses in the intestine and led to exacerbation of colitis. These results identify a monocyte-derived inflammatory DC subset that is associated with the pathogenesis of intestinal inflammation, providing a therapeutic target for the treatment of inflammatory bowel disease. |
| first_indexed | 2024-03-06T20:48:21Z |
| format | Journal article |
| id | oxford-uuid:36b84550-00bc-409a-a757-db69f18b17c0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:48:21Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:36b84550-00bc-409a-a757-db69f18b17c02022-03-26T13:39:32ZE-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:36b84550-00bc-409a-a757-db69f18b17c0EnglishSymplectic Elements at Oxford2010Siddiqui, KLaffont, SPowrie, FDendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-derived inflammatory DCs that express E-cadherin, the receptor for CD103, promote intestinal inflammation. E-cadherin(+) DCs accumulated in the inflamed mesenteric lymph nodes and colon, had high expression of toll-like receptors, and produced colitogenic cytokines, such as IL-6 and IL-23, after activation. Importantly, adoptive transfer of E-cadherin(+) DCs into T cell-restored immunodeficient hosts increased Th17 cell responses in the intestine and led to exacerbation of colitis. These results identify a monocyte-derived inflammatory DC subset that is associated with the pathogenesis of intestinal inflammation, providing a therapeutic target for the treatment of inflammatory bowel disease. |
| spellingShingle | Siddiqui, K Laffont, S Powrie, F E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
| title | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
| title_full | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
| title_fullStr | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
| title_full_unstemmed | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
| title_short | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
| title_sort | e cadherin marks a subset of inflammatory dendritic cells that promote t cell mediated colitis |
| work_keys_str_mv | AT siddiquik ecadherinmarksasubsetofinflammatorydendriticcellsthatpromotetcellmediatedcolitis AT laffonts ecadherinmarksasubsetofinflammatorydendriticcellsthatpromotetcellmediatedcolitis AT powrief ecadherinmarksasubsetofinflammatorydendriticcellsthatpromotetcellmediatedcolitis |