E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.
Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-deri...
Main Authors: | , , |
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Format: | Journal article |
Language: | English |
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2010
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_version_ | 1797062635201495040 |
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author | Siddiqui, K Laffont, S Powrie, F |
author_facet | Siddiqui, K Laffont, S Powrie, F |
author_sort | Siddiqui, K |
collection | OXFORD |
description | Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-derived inflammatory DCs that express E-cadherin, the receptor for CD103, promote intestinal inflammation. E-cadherin(+) DCs accumulated in the inflamed mesenteric lymph nodes and colon, had high expression of toll-like receptors, and produced colitogenic cytokines, such as IL-6 and IL-23, after activation. Importantly, adoptive transfer of E-cadherin(+) DCs into T cell-restored immunodeficient hosts increased Th17 cell responses in the intestine and led to exacerbation of colitis. These results identify a monocyte-derived inflammatory DC subset that is associated with the pathogenesis of intestinal inflammation, providing a therapeutic target for the treatment of inflammatory bowel disease. |
first_indexed | 2024-03-06T20:48:21Z |
format | Journal article |
id | oxford-uuid:36b84550-00bc-409a-a757-db69f18b17c0 |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-06T20:48:21Z |
publishDate | 2010 |
record_format | dspace |
spelling | oxford-uuid:36b84550-00bc-409a-a757-db69f18b17c02022-03-26T13:39:32ZE-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:36b84550-00bc-409a-a757-db69f18b17c0EnglishSymplectic Elements at Oxford2010Siddiqui, KLaffont, SPowrie, FDendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-derived inflammatory DCs that express E-cadherin, the receptor for CD103, promote intestinal inflammation. E-cadherin(+) DCs accumulated in the inflamed mesenteric lymph nodes and colon, had high expression of toll-like receptors, and produced colitogenic cytokines, such as IL-6 and IL-23, after activation. Importantly, adoptive transfer of E-cadherin(+) DCs into T cell-restored immunodeficient hosts increased Th17 cell responses in the intestine and led to exacerbation of colitis. These results identify a monocyte-derived inflammatory DC subset that is associated with the pathogenesis of intestinal inflammation, providing a therapeutic target for the treatment of inflammatory bowel disease. |
spellingShingle | Siddiqui, K Laffont, S Powrie, F E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
title | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
title_full | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
title_fullStr | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
title_full_unstemmed | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
title_short | E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. |
title_sort | e cadherin marks a subset of inflammatory dendritic cells that promote t cell mediated colitis |
work_keys_str_mv | AT siddiquik ecadherinmarksasubsetofinflammatorydendriticcellsthatpromotetcellmediatedcolitis AT laffonts ecadherinmarksasubsetofinflammatorydendriticcellsthatpromotetcellmediatedcolitis AT powrief ecadherinmarksasubsetofinflammatorydendriticcellsthatpromotetcellmediatedcolitis |