Clusterin in Alzheimer’s disease: mechanisms, genetics, and lessons from other pathologies

Clusterin in Alzheimer’s disease: mechanisms, genetics, and lessons from other pathologies

Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several physiological and pathological states, including Alzheimer’s disease (AD). With a prominent extracellular chaperone function, additional roles have been discussed for clusterin, including lipid transport an...

Bibliográfalaš dieđut
Váldodahkkit:	Foster, E, Dangla Valls, A, Lovestone, S, Ribe, E, Buckley, N
Materiálatiipa:	Journal article
Almmustuhtton:	Frontiers Media 2019

Geahča maid

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies
Dahkki: Evangeline M. Foster, et al.
Almmustuhtton: (2019-02-01)

Glycosylated clusterin species facilitate Aβ toxicity in human neurons
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Almmustuhtton: (2022-11-01)

Clusterin is required for β-Amyloid toxicity in human iPSC-derived neurons
Dahkki: Robbins, J, et al.
Almmustuhtton: (2018)

Genetics of clusterin isoform expression and Alzheimer's disease risk.
Dahkki: I-Fang Ling, et al.
Almmustuhtton: (2012-01-01)

Insulin signalling in Alzheimer's disease and diabetes: from epidemiology to molecular links.
Dahkki: Ribe, E, et al.
Almmustuhtton: (2016)

Intraventricular infusion of clusterin ameliorated cognition and pathology in Tg6799 model of Alzheimer’s disease
Dahkki: Xue-Mei Qi, et al.
Almmustuhtton: (2018-01-01)

No diagnostic value of plasma clusterin in Alzheimer's disease.
Dahkki: Edina Silajdžić, et al.
Almmustuhtton: (2012-01-01)

Clusterin/apolipoprotein J, its isoforms and Alzheimer's disease
Dahkki: Giedre Milinkeviciute, et al.
Almmustuhtton: (2023-04-01)

The use of iPSC-derived neurons to investigate the role of clusterin trafficking in Alzheimer’s disease
Dahkki: Foster, EM
Almmustuhtton: (2021)

The association of serum clusterin levels and Clusterin rs11136000 polymorphisms with Alzheimer disease in a Turkish cohort
Dahkki: Gamze Guven, et al.
Almmustuhtton: (2020-01-01)

Genetic variant rs11136000 upregulates clusterin expression and reduces Alzheimer’s disease risk
Dahkki: Jin Ma, et al.
Almmustuhtton: (2022-08-01)

Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke
Dahkki: Galit Weinstein, et al.
Almmustuhtton: (2016-01-01)

Clusterin transduces Alzheimer-risk signals to amyloidogenesis
Dahkki: Xi Liu, et al.
Almmustuhtton: (2022-09-01)

Dynamic changes of CSF clusterin levels across the Alzheimer’s disease continuum
Dahkki: Lian Tang, et al.
Almmustuhtton: (2022-12-01)

Clusterin as a Potential Biomarker of Obesity-Related Alzheimer’s Disease Risk
Dahkki: David Bradley
Almmustuhtton: (2020-10-01)

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Dahkki: Alison Louise Baird, et al.
Almmustuhtton: (2015-11-01)

Blood-based proteomic biomarkers of Alzheimer’s disease pathology
Dahkki: Baird, A, et al.
Almmustuhtton: (2015)

Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
Dahkki: Aleksandra M. Wojtas, et al.
Almmustuhtton: (2020-12-01)

Association between cerebrospinal fluid clusterin and biomarkers of Alzheimer’s disease pathology in mild cognitive impairment: a longitudinal cohort study
Dahkki: Hao Wang, et al.
Almmustuhtton: (2023-10-01)

Direct Interaction of Selenoprotein R with Clusterin and Its Possible Role in Alzheimer's Disease.
Dahkki: Ping Chen, et al.
Almmustuhtton: (2013-01-01)

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Dahkki: Lancaster, T, et al.
Almmustuhtton: (2011)

Development of a Label-Free Immunosensor for Clusterin Detection as an Alzheimer’s Biomarker
Dahkki: Kamrul Islam, et al.
Almmustuhtton: (2018-01-01)

The clinical significance of plasma clusterin and Aβ in the longitudinal follow-up of patients with Alzheimer’s disease
Dahkki: Jung-Lung Hsu, et al.
Almmustuhtton: (2017-11-01)

Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum
Dahkki: Wang J, et al.
Almmustuhtton: (2020-01-01)

Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology
Dahkki: Fading Chen, et al.
Almmustuhtton: (2021-01-01)

Apolipoprotein E genotyping in Alzheimer's disease. The UK Alzheimer's Disease Genetic consortium.
Dahkki: Lovestone, S, et al.
Almmustuhtton: (1996)

Alzheimer’s Disease: From Genetic Variants to the Distinct Pathological Mechanisms
Dahkki: Qiying Sun, et al.
Almmustuhtton: (2017-10-01)

Pathways to Alzheimer’s Disease: The Intersecting Roles of Clusterin and Apolipoprotein E in Amyloid-β Regulation and Neuronal Health
Dahkki: Alexandru Laslo, et al.
Almmustuhtton: (2024-10-01)

The Role of Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review
Dahkki: Muhammad Mazhar Fareed, et al.
Almmustuhtton: (2022-10-01)

Role of Plasma Clusterin in Alzheimer's Disease-A Pilot Study in a Tertiary Hospital in Northern India.
Dahkki: Venugopalan Y Vishnu, et al.
Almmustuhtton: (2016-01-01)

Clusterin induced by OPC phagocytosis blocks IL-9 secretion to inhibit myelination in a model of Alzheimer's disease
Dahkki: Rebecca M. Beiter, et al.
Almmustuhtton: (2025-01-01)

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.
Dahkki: Rojo, A, et al.
Almmustuhtton: (2017)

ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer’s disease
Dahkki: Yi-An Ko, et al.
Almmustuhtton: (2022-12-01)

Analysis of genetic mechanisms, clinical characteristics and pathological changes in familial Alzheimer’s disease and sporadic Alzheimer’s disease
Dahkki: Deng Jiaju, et al.
Almmustuhtton: (2024-01-01)

Genetic and real-world clinical data, combined with empirical validation, nominate Jak-Stat signaling as a target for Alzheimer’s disease therapeutic development
Dahkki: Nevado-Holgado, A, et al.
Almmustuhtton: (2019)

The role of Clusterin in cancer metastasis
Dahkki: Peng M, et al.
Almmustuhtton: (2019-03-01)

Clusterin and Psoriasis; What is the Relation?
Dahkki: Osama Hashem, et al.
Almmustuhtton: (2020-01-01)

Genetics of Alzheimer’s Disease: Lessons Learned in Two Decades
Dahkki: Nilüfer Ertekin Taner
Almmustuhtton: (2010-03-01)

Genetics of Alzheimer’s Disease: Lessons Learned in Two Decades
Dahkki: Nilüfer Ertekin Taner
Almmustuhtton: (2010-03-01)

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology
Dahkki: Ana I. Rojo, et al.
Almmustuhtton: (2017-10-01)