Accurate determination of phenotypic information from historic thoroughbred horses by single base extension

Accurate determination of phenotypic information from historic thoroughbred horses by single base extension

Historic DNA have the potential to identify phenotypic information otherwise invisible in the historical, archaeological and palaeontological record. In order to determine whether a single nucleotide polymorphism typing protocol based on single based extension (SNaPshot™) could produce reliable phen...

Полное описание

Библиографические подробности
Главные авторы: Campana, M, Whitten, C, Edwards, C, Stock, F, Murphy, A, Binns, M, Barker, G, Bower, M
Формат: Journal article
Язык:English
Опубликовано: Public Library of Science 2010
Предметы:
Archaeology
Genetics (life sciences)
Описание
Итог:Historic DNA have the potential to identify phenotypic information otherwise invisible in the historical, archaeological and palaeontological record. In order to determine whether a single nucleotide polymorphism typing protocol based on single based extension (SNaPshot™) could produce reliable phenotypic data from historic samples, we genotyped three coat colour markers for a sample of historic Thoroughbred horses for which both phenotypic and correct geotypic information were known from pedigree information in the General Stud Book. Experimental results were consistent with the pedigrees in all cases. Thus we demonstrate that historic DNA techniques can produce reliable phenotypic information from museum specimens.

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