Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study.
UNLABELLED: We utilised the Hertfordshire cohort study to examine relationships between bone density at baseline and SF-36 status 4 years later. We found deterioration in the mental health domain over follow-up in osteoporotic men (but not women) compared with other groups (relative rate ratio=5.78,...
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797062665531555840 |
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| author | Dennison, E Jameson, K Syddall, H Martin, H Cushnaghan, J Aihie Sayer, A Cooper, C |
| author_facet | Dennison, E Jameson, K Syddall, H Martin, H Cushnaghan, J Aihie Sayer, A Cooper, C |
| author_sort | Dennison, E |
| collection | OXFORD |
| description | UNLABELLED: We utilised the Hertfordshire cohort study to examine relationships between bone density at baseline and SF-36 status 4 years later. We found deterioration in the mental health domain over follow-up in osteoporotic men (but not women) compared with other groups (relative rate ratio=5.78, 95% confidence interval (CI) 1.78-19.2). INTRODUCTION: Osteoporosis is associated with decreased quality of life, although it has been difficult to evaluate the confounding effects of fracture and co-morbidity. Having previously shown that male osteoporotics have poorer health than counterparts with normal bone mineral density, even after adjustment for co-morbidity and prior fracture, we assessed quality of life in both groups 4 years apart. METHODS: Four hundred and ninety-eight men and 468 women completed questionnaires detailing lifestyle factors, co-morbidities and quality of life (SF-36) before undergoing bone density measurements at the lumbar spine and total femur. At follow-up 4 years later, 322 men and 320 women were reassessed. RESULTS: Multinomial logistic regression confirmed deterioration in mental health over follow-up in osteoporotic men compared with other groups (relative rate ratio=5.78, 95% CI 1.78-19.2). These patterns were not apparent among women. CONCLUSIONS: Men with lower bone density at baseline had poorer quality of life some 4 years later, even after adjustment for co-morbidity and fracture. This may reflect secondary osteoporosis in men (due to alcohol or hypogonadism). |
| first_indexed | 2024-03-06T20:48:48Z |
| format | Journal article |
| id | oxford-uuid:36db6cc2-fa12-48a5-958c-1ee42aaa8ca9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:48:48Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:36db6cc2-fa12-48a5-958c-1ee42aaa8ca92022-03-26T13:40:29ZBone health and deterioration in quality of life among participants from the Hertfordshire cohort study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:36db6cc2-fa12-48a5-958c-1ee42aaa8ca9EnglishSymplectic Elements at Oxford2010Dennison, EJameson, KSyddall, HMartin, HCushnaghan, JAihie Sayer, ACooper, CUNLABELLED: We utilised the Hertfordshire cohort study to examine relationships between bone density at baseline and SF-36 status 4 years later. We found deterioration in the mental health domain over follow-up in osteoporotic men (but not women) compared with other groups (relative rate ratio=5.78, 95% confidence interval (CI) 1.78-19.2). INTRODUCTION: Osteoporosis is associated with decreased quality of life, although it has been difficult to evaluate the confounding effects of fracture and co-morbidity. Having previously shown that male osteoporotics have poorer health than counterparts with normal bone mineral density, even after adjustment for co-morbidity and prior fracture, we assessed quality of life in both groups 4 years apart. METHODS: Four hundred and ninety-eight men and 468 women completed questionnaires detailing lifestyle factors, co-morbidities and quality of life (SF-36) before undergoing bone density measurements at the lumbar spine and total femur. At follow-up 4 years later, 322 men and 320 women were reassessed. RESULTS: Multinomial logistic regression confirmed deterioration in mental health over follow-up in osteoporotic men compared with other groups (relative rate ratio=5.78, 95% CI 1.78-19.2). These patterns were not apparent among women. CONCLUSIONS: Men with lower bone density at baseline had poorer quality of life some 4 years later, even after adjustment for co-morbidity and fracture. This may reflect secondary osteoporosis in men (due to alcohol or hypogonadism). |
| spellingShingle | Dennison, E Jameson, K Syddall, H Martin, H Cushnaghan, J Aihie Sayer, A Cooper, C Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study. |
| title | Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study. |
| title_full | Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study. |
| title_fullStr | Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study. |
| title_full_unstemmed | Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study. |
| title_short | Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study. |
| title_sort | bone health and deterioration in quality of life among participants from the hertfordshire cohort study |
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