Plasma cytokines and risk of coronary heart disease in the PROCARDIS study
<strong>Objective</strong> The aims of the study were to examine the associations of plasma levels of five cytokines (interleukin (IL)-6, IL-5, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and IL-6 receptor (IL-6R)) and C reactive protein (CRP) with risk of coronary hea...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
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BMJ Publishing Group
2018
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| _version_ | 1797062665732882432 |
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| author | Clarke, R Valdes-Marquez, E Hill, M Gordon, J Farrall, M Hamsten, A Watkins, H Hopewell, J |
| author_facet | Clarke, R Valdes-Marquez, E Hill, M Gordon, J Farrall, M Hamsten, A Watkins, H Hopewell, J |
| author_sort | Clarke, R |
| collection | OXFORD |
| description | <strong>Objective</strong> The aims of the study were to examine the associations of plasma levels of five cytokines (interleukin (IL)-6, IL-5, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and IL-6 receptor (IL-6R)) and C reactive protein (CRP) with risk of coronary heart disease (CHD). <strong>Methods:</strong> In a case–control study of 931 CHD cases and 974 controls, logistic regression was used to estimate the OR and 95% CI of CHD for extreme thirds of biomarkers after adjustment for established risk factors. Sensitivity analyses were conducted in non-statin and in non-aspirin users. <strong>Results:</strong> Plasma levels of CRP were moderately correlated with IL-6 (r=0.45) in controls, but more weakly correlated with other cytokines. Likewise, all other cytokines were only weakly correlated with each other. After adjustment for established risk factors, the ORs (95% CI) for CHD comparing extreme thirds of cytokine levels (defined in controls) were 2.53 (1.86 to 3.43) for IL-6, 1.46 (1.11 to 1.93) for IL-5 and 1.46 (1.09 to 1.95) for IFN-γ, respectively. However, neither TNF-α, IL-6R nor CRP was significantly associated with CHD. After further adjustment for the associated cytokines, only IL-5 (1.34; 1.00 to 1.80) and IL-6 (2.39; 1.73 to 3.30) remained significantly associated with CHD. The risk associations of cytokines in non-users of statins or aspirin were comparable with the overall population. <strong>Conclusions:</strong> This study confirmed the importance of IL-6 as the most strongly associated cytokine with CHD risk, but also demonstrated novel and independent associations of IL-5 with CHD that warrant further investigation using larger panels of cytokines. |
| first_indexed | 2024-03-06T20:48:48Z |
| format | Journal article |
| id | oxford-uuid:36dbce59-b78e-43c8-92a2-992a502c6a29 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:48:48Z |
| publishDate | 2018 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:36dbce59-b78e-43c8-92a2-992a502c6a292022-03-26T13:40:31ZPlasma cytokines and risk of coronary heart disease in the PROCARDIS studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:36dbce59-b78e-43c8-92a2-992a502c6a29Symplectic Elements at OxfordBMJ Publishing Group2018Clarke, RValdes-Marquez, EHill, MGordon, JFarrall, MHamsten, AWatkins, HHopewell, J<strong>Objective</strong> The aims of the study were to examine the associations of plasma levels of five cytokines (interleukin (IL)-6, IL-5, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and IL-6 receptor (IL-6R)) and C reactive protein (CRP) with risk of coronary heart disease (CHD). <strong>Methods:</strong> In a case–control study of 931 CHD cases and 974 controls, logistic regression was used to estimate the OR and 95% CI of CHD for extreme thirds of biomarkers after adjustment for established risk factors. Sensitivity analyses were conducted in non-statin and in non-aspirin users. <strong>Results:</strong> Plasma levels of CRP were moderately correlated with IL-6 (r=0.45) in controls, but more weakly correlated with other cytokines. Likewise, all other cytokines were only weakly correlated with each other. After adjustment for established risk factors, the ORs (95% CI) for CHD comparing extreme thirds of cytokine levels (defined in controls) were 2.53 (1.86 to 3.43) for IL-6, 1.46 (1.11 to 1.93) for IL-5 and 1.46 (1.09 to 1.95) for IFN-γ, respectively. However, neither TNF-α, IL-6R nor CRP was significantly associated with CHD. After further adjustment for the associated cytokines, only IL-5 (1.34; 1.00 to 1.80) and IL-6 (2.39; 1.73 to 3.30) remained significantly associated with CHD. The risk associations of cytokines in non-users of statins or aspirin were comparable with the overall population. <strong>Conclusions:</strong> This study confirmed the importance of IL-6 as the most strongly associated cytokine with CHD risk, but also demonstrated novel and independent associations of IL-5 with CHD that warrant further investigation using larger panels of cytokines. |
| spellingShingle | Clarke, R Valdes-Marquez, E Hill, M Gordon, J Farrall, M Hamsten, A Watkins, H Hopewell, J Plasma cytokines and risk of coronary heart disease in the PROCARDIS study |
| title | Plasma cytokines and risk of coronary heart disease in the PROCARDIS study |
| title_full | Plasma cytokines and risk of coronary heart disease in the PROCARDIS study |
| title_fullStr | Plasma cytokines and risk of coronary heart disease in the PROCARDIS study |
| title_full_unstemmed | Plasma cytokines and risk of coronary heart disease in the PROCARDIS study |
| title_short | Plasma cytokines and risk of coronary heart disease in the PROCARDIS study |
| title_sort | plasma cytokines and risk of coronary heart disease in the procardis study |
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