Diabetes mellitus and the β cell: the last ten years.
Diabetes is a major global problem. During the past decade, the genetic basis of various monogenic forms of the disease, and their underlying molecular mechanisms, have been elucidated. Many genes that increase type 2 diabetes (T2DM) risk have also been identified, but how they do so remains enigmat...
| Principais autores: | , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2012
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| _version_ | 1826267093778038784 |
|---|---|
| author | Ashcroft, F Rorsman, P |
| author_facet | Ashcroft, F Rorsman, P |
| author_sort | Ashcroft, F |
| collection | OXFORD |
| description | Diabetes is a major global problem. During the past decade, the genetic basis of various monogenic forms of the disease, and their underlying molecular mechanisms, have been elucidated. Many genes that increase type 2 diabetes (T2DM) risk have also been identified, but how they do so remains enigmatic. Nevertheless, defective insulin secretion emerges as the main culprit in both monogenic and polygenic diabetes, with environmental and lifestyle factors, via obesity, accounting for the current dramatic increase in T2DM. There also have been significant advances in therapy, particularly for some monogenic disorders. We review here what ails the β cell and how its function may be restored. |
| first_indexed | 2024-03-06T20:48:53Z |
| format | Journal article |
| id | oxford-uuid:36e7cf02-fa6e-4aad-bd8c-c0adb7022079 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:48:53Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:36e7cf02-fa6e-4aad-bd8c-c0adb70220792022-03-26T13:40:41ZDiabetes mellitus and the β cell: the last ten years.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:36e7cf02-fa6e-4aad-bd8c-c0adb7022079EnglishSymplectic Elements at Oxford2012Ashcroft, FRorsman, PDiabetes is a major global problem. During the past decade, the genetic basis of various monogenic forms of the disease, and their underlying molecular mechanisms, have been elucidated. Many genes that increase type 2 diabetes (T2DM) risk have also been identified, but how they do so remains enigmatic. Nevertheless, defective insulin secretion emerges as the main culprit in both monogenic and polygenic diabetes, with environmental and lifestyle factors, via obesity, accounting for the current dramatic increase in T2DM. There also have been significant advances in therapy, particularly for some monogenic disorders. We review here what ails the β cell and how its function may be restored. |
| spellingShingle | Ashcroft, F Rorsman, P Diabetes mellitus and the β cell: the last ten years. |
| title | Diabetes mellitus and the β cell: the last ten years. |
| title_full | Diabetes mellitus and the β cell: the last ten years. |
| title_fullStr | Diabetes mellitus and the β cell: the last ten years. |
| title_full_unstemmed | Diabetes mellitus and the β cell: the last ten years. |
| title_short | Diabetes mellitus and the β cell: the last ten years. |
| title_sort | diabetes mellitus and the β cell the last ten years |
| work_keys_str_mv | AT ashcroftf diabetesmellitusandthebcellthelasttenyears AT rorsmanp diabetesmellitusandthebcellthelasttenyears |