Characterization of the molten globule state of retinol-binding protein using a molecular dynamics simulation approach.

Retinol-binding protein transports retinol, and circulates in the plasma as a macromolecular complex with the protein transthyretin. Under acidic conditions retinol-binding protein undergoes a transition to the molten globule state, and releases the bound retinol ligand. A biased molecular dynamics...

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Váldodahkkit: Paci, E, Greene, L, Jones, R, Smith, L
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 2005