Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam.
During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV)--an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic struc...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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| _version_ | 1826267135292211200 |
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| author | My, P Rabaa, M Donato, C Cowley, D Phat, V Dung, T Anh, P Vinh, H Bryant, J Kellam, P Thwaites, G Woolhouse, M Kirkwood, C Baker, S |
| author_facet | My, P Rabaa, M Donato, C Cowley, D Phat, V Dung, T Anh, P Vinh, H Bryant, J Kellam, P Thwaites, G Woolhouse, M Kirkwood, C Baker, S |
| author_sort | My, P |
| collection | OXFORD |
| description | During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV)--an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26-P[19]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1-3 and NSP2-5). We proposed that this G26P[19] strain was the product of zoonotic transmission coupled with one or more reassortment events occurring in human and/or animal reservoirs. The identification of such strains has potential implications for vaccine efficacy in south-east Asia, and outlines the utility of whole-genome sequencing for studying RV diversity and zoonotic potential during disease surveillance. |
| first_indexed | 2024-03-06T20:49:34Z |
| format | Journal article |
| id | oxford-uuid:371dd45b-5eb2-443b-a205-3fb7f127891d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:49:34Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:371dd45b-5eb2-443b-a205-3fb7f127891d2022-03-26T13:42:03ZNovel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:371dd45b-5eb2-443b-a205-3fb7f127891dEnglishSymplectic Elements at Oxford2014My, PRabaa, MDonato, CCowley, DPhat, VDung, TAnh, PVinh, HBryant, JKellam, PThwaites, GWoolhouse, MKirkwood, CBaker, SDuring a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV)--an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26-P[19]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1-3 and NSP2-5). We proposed that this G26P[19] strain was the product of zoonotic transmission coupled with one or more reassortment events occurring in human and/or animal reservoirs. The identification of such strains has potential implications for vaccine efficacy in south-east Asia, and outlines the utility of whole-genome sequencing for studying RV diversity and zoonotic potential during disease surveillance. |
| spellingShingle | My, P Rabaa, M Donato, C Cowley, D Phat, V Dung, T Anh, P Vinh, H Bryant, J Kellam, P Thwaites, G Woolhouse, M Kirkwood, C Baker, S Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam. |
| title | Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam. |
| title_full | Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam. |
| title_fullStr | Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam. |
| title_full_unstemmed | Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam. |
| title_short | Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam. |
| title_sort | novel porcine like human g26p 19 rotavirus identified in hospitalized paediatric diarrhoea patients in ho chi minh city vietnam |
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