Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases.
Forty two cases of confirmed hepatitis C virus (HCV) infection with available liver histology were studied. Most patients, 23 of 42 (55%) had abnormal liver function tests but 19 of 42 (45%) had persistently normal liver transaminases (mean aspartate transaminase (AST) 24.1 IU/l, mean follow up 10 m...
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| Format: | Journal article |
| Language: | English |
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1995
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| _version_ | 1797062732260835328 |
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| author | Healey, C Chapman, R Fleming, K |
| author_facet | Healey, C Chapman, R Fleming, K |
| author_sort | Healey, C |
| collection | OXFORD |
| description | Forty two cases of confirmed hepatitis C virus (HCV) infection with available liver histology were studied. Most patients, 23 of 42 (55%) had abnormal liver function tests but 19 of 42 (45%) had persistently normal liver transaminases (mean aspartate transaminase (AST) 24.1 IU/l, mean follow up 10 months). Histological examinations in the group with normal AST activities were normal in two of 19 (11%), showed non-specific reactive hepatitis in eight of 19 (42%), chronic persistent hepatitis in six of 19 (31%), and chronic active hepatitis in three of 19 (16%). Twenty three of 42 (55%) had either persistently or temporary raised liver transaminases (mean AST 96.2 IU/l, mean follow up 16 months). Histological examinations in this second group with abnormal liver biochemistry showed reactive hepatitis in five of 23 (22%), chronic persistent hepatitis in six of 23 (26%), chronic active hepatitis in 10 of 23 (43%), and cirrhosis in two (9%). Average alcohol intake was significantly higher in the group within abnormal liver function (17.8 v 6.4 units, p = 0.01). Although serious pathology was more frequent in the abnormal transaminase group, significant liver pathology (chronic persistent hepatitis or chronic active hepatitis) was found in nine of 19 (47%) of cases with repeatedly normal transaminases. Liver biopsy is advised in all cases of chronic hepatitis C infection to accurately assess both the degree of fibrosis and the current activity of the disease. |
| first_indexed | 2024-03-06T20:49:46Z |
| format | Journal article |
| id | oxford-uuid:372ace3f-3805-4ad5-899d-ddbf3d20463f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:49:46Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:372ace3f-3805-4ad5-899d-ddbf3d20463f2022-03-26T13:42:27ZLiver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:372ace3f-3805-4ad5-899d-ddbf3d20463fEnglishSymplectic Elements at Oxford1995Healey, CChapman, RFleming, KForty two cases of confirmed hepatitis C virus (HCV) infection with available liver histology were studied. Most patients, 23 of 42 (55%) had abnormal liver function tests but 19 of 42 (45%) had persistently normal liver transaminases (mean aspartate transaminase (AST) 24.1 IU/l, mean follow up 10 months). Histological examinations in the group with normal AST activities were normal in two of 19 (11%), showed non-specific reactive hepatitis in eight of 19 (42%), chronic persistent hepatitis in six of 19 (31%), and chronic active hepatitis in three of 19 (16%). Twenty three of 42 (55%) had either persistently or temporary raised liver transaminases (mean AST 96.2 IU/l, mean follow up 16 months). Histological examinations in this second group with abnormal liver biochemistry showed reactive hepatitis in five of 23 (22%), chronic persistent hepatitis in six of 23 (26%), chronic active hepatitis in 10 of 23 (43%), and cirrhosis in two (9%). Average alcohol intake was significantly higher in the group within abnormal liver function (17.8 v 6.4 units, p = 0.01). Although serious pathology was more frequent in the abnormal transaminase group, significant liver pathology (chronic persistent hepatitis or chronic active hepatitis) was found in nine of 19 (47%) of cases with repeatedly normal transaminases. Liver biopsy is advised in all cases of chronic hepatitis C infection to accurately assess both the degree of fibrosis and the current activity of the disease. |
| spellingShingle | Healey, C Chapman, R Fleming, K Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases. |
| title | Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases. |
| title_full | Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases. |
| title_fullStr | Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases. |
| title_full_unstemmed | Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases. |
| title_short | Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases. |
| title_sort | liver histology in hepatitis c infection a comparison between patients with persistently normal or abnormal transaminases |
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