Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial.
Malaria in pregnancy is associated with maternal and fetal morbidity and mortality. In 2006, WHO recommended use of artemisinin-based combination treatments during the second or third trimesters, but data on efficacy and safety in Africa were scarce. We aimed to assess whether artemether-lumefantrin...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2010
|
| _version_ | 1797062745059753984 |
|---|---|
| author | Piola, P Nabasumba, C Turyakira, E Dhorda, M Lindegardh, N Nyehangane, D Snounou, G Ashley, E Mcgready, R Nosten, F Guerin, P |
| author_facet | Piola, P Nabasumba, C Turyakira, E Dhorda, M Lindegardh, N Nyehangane, D Snounou, G Ashley, E Mcgready, R Nosten, F Guerin, P |
| author_sort | Piola, P |
| collection | OXFORD |
| description | Malaria in pregnancy is associated with maternal and fetal morbidity and mortality. In 2006, WHO recommended use of artemisinin-based combination treatments during the second or third trimesters, but data on efficacy and safety in Africa were scarce. We aimed to assess whether artemether-lumefantrine was at least as efficacious as oral quinine for the treatment of uncomplicated falciparum malaria during the second and third trimesters of pregnancy in Mbarara, Uganda. |
| first_indexed | 2024-03-06T20:49:57Z |
| format | Journal article |
| id | oxford-uuid:373b510a-c84d-470e-9ebb-87cc9f826098 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:49:57Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:373b510a-c84d-470e-9ebb-87cc9f8260982022-03-26T13:42:47ZEfficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:373b510a-c84d-470e-9ebb-87cc9f826098EnglishSymplectic Elements at Oxford2010Piola, PNabasumba, CTuryakira, EDhorda, MLindegardh, NNyehangane, DSnounou, GAshley, EMcgready, RNosten, FGuerin, PMalaria in pregnancy is associated with maternal and fetal morbidity and mortality. In 2006, WHO recommended use of artemisinin-based combination treatments during the second or third trimesters, but data on efficacy and safety in Africa were scarce. We aimed to assess whether artemether-lumefantrine was at least as efficacious as oral quinine for the treatment of uncomplicated falciparum malaria during the second and third trimesters of pregnancy in Mbarara, Uganda. |
| spellingShingle | Piola, P Nabasumba, C Turyakira, E Dhorda, M Lindegardh, N Nyehangane, D Snounou, G Ashley, E Mcgready, R Nosten, F Guerin, P Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial. |
| title | Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial. |
| title_full | Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial. |
| title_fullStr | Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial. |
| title_full_unstemmed | Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial. |
| title_short | Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial. |
| title_sort | efficacy and safety of artemether lumefantrine compared with quinine in pregnant women with uncomplicated plasmodium falciparum malaria an open label randomised non inferiority trial |
| work_keys_str_mv | AT piolap efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT nabasumbac efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT turyakirae efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT dhordam efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT lindegardhn efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT nyehanganed efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT snounoug efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT ashleye efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT mcgreadyr efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT nostenf efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial AT guerinp efficacyandsafetyofartemetherlumefantrinecomparedwithquinineinpregnantwomenwithuncomplicatedplasmodiumfalciparummalariaanopenlabelrandomisednoninferioritytrial |