Interaction of anesthetics with open and closed conformations of a potassium channel studied via molecular dynamics and normal mode analysis.

Interaction of anesthetics with open and closed conformations of a potassium channel studied via molecular dynamics and normal mode analysis.

A variety of experiments suggest that membrane proteins are important targets of anesthetic molecules, and that ion channels interact differently with anesthetics in their open and closed conformations. The availability of an open and a closed structural model for the KirBac1.1 potassium channel has...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Vemparala, S, Domene, C, Klein, M
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2008

समान संसाधन

Computational studies on the interactions of inhalational anesthetics with proteins.
द्वारा: Vemparala, S, और अन्य
प्रकाशित: (2010)

Molecular dynamics simulation of open and close confirmations of KirBac1.1 in explicit lipid billayer: Structural changes and aromatic localization at lipid/water interface
द्वारा: Vemparala, S, और अन्य
प्रकाशित: (2005)

The role of conformation in ion permeation in a K+ channel.
द्वारा: Domene, C, और अन्य
प्रकाशित: (2008)

Conformational changes and gating at the selectivity filter of potassium channels.
द्वारा: Domene, C, और अन्य
प्रकाशित: (2008)

Role of aromatic localization in the gating process of a potassium channel.
द्वारा: Domene, C, और अन्य
प्रकाशित: (2006)

Role of aromatic localization in the gating process of a potassium channel.
द्वारा: Domene, C, और अन्य
प्रकाशित: (2006)

Molecular dynamics simulations of potassium channels
द्वारा: Domene, C
प्रकाशित: (2007)

Capturing the Molecular Mechanism of Anesthetic Action by Simulation Methods
द्वारा: Oakes, V, और अन्य
प्रकाशित: (2018)

Modeling of an ion channel in its open conformation.
द्वारा: Domene, C, और अन्य
प्रकाशित: (2005)

On ionic conduction in potassium channels.
द्वारा: Domene, C, और अन्य
प्रकाशित: (2010)

Atypical mechanism of conduction in potassium channels.
द्वारा: Furini, S, और अन्य
प्रकाशित: (2009)

Anionic phospholipid interactions with the potassium channel KcsA: simulation studies.
द्वारा: Deol, S, और अन्य
प्रकाशित: (2006)

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.
द्वारा: Kuo, A, और अन्य
प्रकाशित: (2005)

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.
द्वारा: Kuo, A, और अन्य
प्रकाशित: (2005)

Many-body effects and simulations of potassium channels
द्वारा: Illingworth, C, और अन्य
प्रकाशित: (2009)

Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.
द्वारा: Grottesi, A, और अन्य
प्रकाशित: (2005)

Conformational dynamics of M2 helices in KirBac channels: helix flexibility in relation to gating via molecular dynamics simulations.
द्वारा: Grottesi, A, और अन्य
प्रकाशित: (2005)

Open-state models of a potassium channel.
द्वारा: Biggin, P, और अन्य
प्रकाशित: (2002)

Location and character of volatile general anesthetics binding sites in the transmembrane domain of TRPV1
द्वारा: Jorgensen, C, और अन्य
प्रकाशित: (2018)

Characterization of protein conformational states by normal-mode frequencies.
द्वारा: Hall, B, और अन्य
प्रकाशित: (2007)

Radiolytic Footprinting Reveals Conformational Changes During Potassium Channel Gating
द्वारा: Gupta, S, और अन्य
प्रकाशित: (2010)

Ultrasound in anesthetic practice /
द्वारा: Arthurs, Graham, और अन्य
प्रकाशित: (2009)

Molecular simulations and lipid-protein interactions: potassium channels and other membrane proteins.
द्वारा: Sansom, MS, और अन्य
प्रकाशित: (2005)

Calcium-evoked opening of potassium channels in hamster eggs.
द्वारा: Georgiou, P, और अन्य
प्रकाशित: (1983)

A closed-loop anesthetic delivery system for real-time control of burst suppression
द्वारा: Chemali, Jessica, और अन्य
प्रकाशित: (2016)

Potassium and sodium ions in a potassium channel studied by molecular dynamics simulations.
द्वारा: Biggin, P, और अन्य
प्रकाशित: (2001)

Conformational dynamics of helix S6 from Shaker potassium channel: simulation studies.
द्वारा: Bright, J, और अन्य
प्रकाशित: (2002)

K(+) and Na(+) conduction in selective and nonselective ion channels via molecular dynamics simulations.
द्वारा: Furini, S, और अन्य
प्रकाशित: (2013)

The ligand-sensitive gate of a potassium channel lies close to the selectivity filter
द्वारा: Proks, P, और अन्य
प्रकाशित: (2002)

The ligand-sensitive gate of a potassium channel lies close to the selectivity filter.
द्वारा: Proks, P, और अन्य
प्रकाशित: (2003)

The ligand-sensitive gate of a potassium channel lies close to the selectivity filter
द्वारा: Proks, P, और अन्य
प्रकाशित: (2003)

Crystal structure of the potassium channel KirBac1.1 in the closed state.
द्वारा: Kuo, A, और अन्य
प्रकाशित: (2003)

Open and closed mode of online discussion - does it matter?
द्वारा: Abd. Jalil, Habibah, और अन्य
प्रकाशित: (2010)

Kinetics of local anesthetic binding to sodium channels : role of pKaÌ³
द्वारा: Chernoff, Daniel Michael
प्रकाशित: (2005)

KcsA closed and open: modelling and simulation studies.
द्वारा: Holyoake, J, और अन्य
प्रकाशित: (2004)

Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry.
द्वारा: Gupta, S, और अन्य
प्रकाशित: (2010)

Ion channel gating: insights via molecular simulations.
द्वारा: Beckstein, O, और अन्य
प्रकाशित: (2003)

Molecular modelling of human and C-elegans TWIK potassium channels
द्वारा: Law, R, और अन्य
प्रकाशित: (2000)

THE ELECTRO-REDUCTION OF THE ANESTHETIC GAS ISOFLURANE
द्वारा: Compton, R, और अन्य
प्रकाशित: (1988)

Potassium channel regulation.
द्वारा: Campbell, J, और अन्य
प्रकाशित: (2003)