High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.
Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1826267211301388288 |
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| author | Babiker, H Pringle, S Abdel-Muhsin, A Mackinnon, M Hunt, P Walliker, D |
| author_facet | Babiker, H Pringle, S Abdel-Muhsin, A Mackinnon, M Hunt, P Walliker, D |
| author_sort | Babiker, H |
| collection | OXFORD |
| description | Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance gene pfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance. |
| first_indexed | 2024-03-06T20:50:43Z |
| format | Journal article |
| id | oxford-uuid:377ab4cd-8967-406f-bf99-4f28428a3e21 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:50:43Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:377ab4cd-8967-406f-bf99-4f28428a3e212022-03-26T13:44:12ZHigh-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:377ab4cd-8967-406f-bf99-4f28428a3e21EnglishSymplectic Elements at Oxford2001Babiker, HPringle, SAbdel-Muhsin, AMackinnon, MHunt, PWalliker, DPolymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance gene pfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance. |
| spellingShingle | Babiker, H Pringle, S Abdel-Muhsin, A Mackinnon, M Hunt, P Walliker, D High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. |
| title | High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. |
| title_full | High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. |
| title_fullStr | High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. |
| title_full_unstemmed | High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. |
| title_short | High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. |
| title_sort | high level chloroquine resistance in sudanese isolates of plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1 |
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