Variation across the allele frequency spectrum.
A new study finds that individuals with high plasma triglyceride levels carry approximately twice as many rare, coding genetic variants within four candidate genes identified through genome-wide association studies than individuals without these high levels. This study demonstrates the overlap of ra...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826267215060533248 |
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| author | Gloyn, A McCarthy, M |
| author_facet | Gloyn, A McCarthy, M |
| author_sort | Gloyn, A |
| collection | OXFORD |
| description | A new study finds that individuals with high plasma triglyceride levels carry approximately twice as many rare, coding genetic variants within four candidate genes identified through genome-wide association studies than individuals without these high levels. This study demonstrates the overlap of rare and common variant signals at loci associated with lipid levels and shows the value of efforts to extend susceptibility variant discovery to embrace the full allele-frequency spectrum. © 2010 Nature America, Inc. All rights reserved. |
| first_indexed | 2024-03-06T20:50:46Z |
| format | Journal article |
| id | oxford-uuid:377e4a28-d228-4a77-b299-38e2605354ba |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:50:46Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:377e4a28-d228-4a77-b299-38e2605354ba2022-03-26T13:44:18ZVariation across the allele frequency spectrum.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:377e4a28-d228-4a77-b299-38e2605354baEnglishSymplectic Elements at Oxford2010Gloyn, AMcCarthy, MA new study finds that individuals with high plasma triglyceride levels carry approximately twice as many rare, coding genetic variants within four candidate genes identified through genome-wide association studies than individuals without these high levels. This study demonstrates the overlap of rare and common variant signals at loci associated with lipid levels and shows the value of efforts to extend susceptibility variant discovery to embrace the full allele-frequency spectrum. © 2010 Nature America, Inc. All rights reserved. |
| spellingShingle | Gloyn, A McCarthy, M Variation across the allele frequency spectrum. |
| title | Variation across the allele frequency spectrum. |
| title_full | Variation across the allele frequency spectrum. |
| title_fullStr | Variation across the allele frequency spectrum. |
| title_full_unstemmed | Variation across the allele frequency spectrum. |
| title_short | Variation across the allele frequency spectrum. |
| title_sort | variation across the allele frequency spectrum |
| work_keys_str_mv | AT gloyna variationacrosstheallelefrequencyspectrum AT mccarthym variationacrosstheallelefrequencyspectrum |