Asymmetric synthesis of cyclic beta-amino acids and cyclic amines via sequential diastereoselective conjugate addition and ring closing metathesis

Asymmetric synthesis of cyclic beta-amino acids and cyclic amines via sequential diastereoselective conjugate addition and ring closing metathesis

Diastereoselective conjugate addition of lithium (S)-N-allyl-N-α-methylbenzylamide to a range of α,β-unsaturated esters followed by ring closing metathesis is used to afford efficiently a range of substituted cyclic β-amino esters in high d.e. Alternatively, conjugate addition to α,β-unsaturated Wei...

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Dettagli Bibliografici
Autori principali:	Chippindale, A, Davies, S, Iwamoto, K, Parkin, R, Smethurst, C, Smith, A, Rodriguez-Solla, H
Natura:	Journal article
Pubblicazione:	2003

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