Ccx282-B, an orally active inhibitor of chemokine receptor Ccr9, shows anti-inflammatory and clinical activity in the treatment of Crohn's disease

Ccx282-B, an orally active inhibitor of chemokine receptor Ccr9, shows anti-inflammatory and clinical activity in the treatment of Crohn's disease

Dades bibliogràfiques
Autors principals:	Keshav, S, Ungashe, S, Zheng, W, Belker, P, Wright, K, Schall, T
Format:	Conference item
Publicat:	2007

Ítems similars

Traficet-EN (CCX282-B), an orally active inhibitor of chemokine receptor CCR9, for treatment of Crohn's disease
per: Bekker, P, et al.
Publicat: (2007)

Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease.
per: Walters, M, et al.
Publicat: (2010)

MEDI 167-Discovery of the highly potent, selective and orally bioavailable CCR9 antagonist CCX282-B
per: Ungashe, S, et al.
Publicat: (2008)

A randomized controlled trial of the efficacy and safety of CCX282-B, an orally-administered blocker of chemokine receptor CCR9, for patients with Crohn's disease.
per: Satish Keshav, et al.
Publicat: (2013-01-01)

PROTECT-1 Maintenance Phase Study Results demonstrate efficacy of the Intestine-Specific Chemokine Receptor Antagonist CCX282-B (Traficet-EN) in Crohn's Disease
per: Bekker, P, et al.
Publicat: (2009)

PROTECT-1 Study Demonstrated Efficacy of the Intestine-Specific Chemokine Receptor Antagonist CCX282-B (Traficet-EN) in Treatment of Patients with Moderate to Severe Crohn's Disease
per: Keshav, S, et al.
Publicat: (2009)

PROTECT-1: A prospective randomized trial of CCX282-B (Traficet-EN), a novel oral therapy targeting chemokine receptor 9 in Crohn's disease
per: Keshav, S, et al.
Publicat: (2007)

Protect-1, a prospective randomized oral therapy evaluation of CCX282-B (Traficet-EN) in Crohn's disease trial
per: Bekker, P, et al.
Publicat: (2008)

Pharmacological inhibition of CCR9 is a novel approach in the treatment of inflammatory bowel disease
per: Bekker, P, et al.
Publicat: (2007)

Cc chemokine receptor 9 (ccr9) antagonist ameliorates experimental ileitis and colitis
per: Wei, Z, et al.
Publicat: (2005)

Expression of CCR8 and CCX-CKR on Basophils in Chronic Urticaria Is Amplified by IgE-Mediated Activation
per: Ewa A. Bartko, et al.
Publicat: (2023-05-01)

Traficet-EN, an Oral CCR9-Specific Antagonist, induces high levels of remission in the open-label Phase of PROTECT-1 in Crohn's Disease
per: Bekker, P, et al.
Publicat: (2008)

Traficet-EN, an oral CCR9-specific antagonist, induces high levels of remission in the open-label phase of PROTECT-1 in Crohn's disease
per: Bekker, P, et al.
Publicat: (2008)

CCR9 antagonism: potential in the treatment of Inflammatory Bowel Disease.
per: Wendt, E, et al.
Publicat: (2015)

CCR9 antagonism: potential in the treatment of Inflammatory Bowel Disease
per: Wendt E, et al.
Publicat: (2015-04-01)

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
per: Hui Zhang, et al.
Publicat: (2021-07-01)

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
per: Zhehua Shao, et al.
Publicat: (2022-05-01)

Antagonist of chemokine receptors CCR1 and CCR3
per: Ammit Alaina, et al.
Publicat: (2000-11-01)

Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19.
per: Daniel Clark Files, et al.
Publicat: (2022-06-01)

Milligram production and biological activity characterization of the human chemokine receptor CCR3.
per: Mingqing Wang, et al.
Publicat: (2013-01-01)

CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity.
per: Kathleen M C Sullivan, et al.
Publicat: (2023-01-01)

Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation
per: Julia M. Laufer, et al.
Publicat: (2019-10-01)

Role of the chemokine receptors CCR1, CCR2 and CCR4 in the pathogenesis of experimental dengue infection in mice.
per: Rodrigo Guabiraba, et al.
Publicat: (2010-01-01)

CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells.
per: Greaves, D, et al.
Publicat: (1997)

Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis
per: Yamaguchi Kazuhiro, et al.
Publicat: (2009-08-01)

Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
per: David Jonathan Wasilko, et al.
Publicat: (2020-06-01)

Constitutively active CCR5 chemokine receptors differ in mediating HIV envelope-dependent fusion.
per: Alex de Voux, et al.
Publicat: (2013-01-01)

Identification and Expression Profiling Analysis of the Cation/Ca2+ Exchanger (CCX) Gene Family: Overexpression of SlCCX1-LIKE Regulates the Leaf Senescence in Tomato Flowering Phase
per: Jiao Li, et al.
Publicat: (2021-06-01)

Expression and function of the chemokine receptor CCR7 in thyroid carcinomas.
per: Sancho, M, et al.
Publicat: (2006)

The role of chemokines and chemokine receptors in eosinophil activation during inflammatory allergic reactions
per: Oliveira S.H.P., et al.
Publicat: (2003-01-01)

CCR9 Antagonists in the Treatment of Ulcerative Colitis
per: Pirow Bekker, et al.
Publicat: (2015-01-01)

A systemically-administered small molecule antagonist of CCR9 acts as a tissue-selective inhibitor of lymphocyte trafficking.
per: Noah J Tubo, et al.
Publicat: (2012-01-01)

Chemokine Receptor Ccr6 Deficiency Alters Hepatic Inflammatory Cell Recruitment and Promotes Liver Inflammation and Fibrosis.
per: Silvia Affò, et al.
Publicat: (2015-01-01)

Non-redundant roles of the CCR1 and CCR2 chemokine axes in monocyte recruitment during lung metastasis
per: Alessia G. Liner, et al.
Publicat: (2025-01-01)

Activation of CCR2+ human proinflammatory monocytes by human herpesvirus-6B chemokine N-terminal peptide.
per: Clark, D, et al.
Publicat: (2013)

Alterations in chemokine receptor CCR5 activity influence tumor cell biology in human cholangiocarcinoma cell lines
per: Jiaqi Yang, et al.
Publicat: (2021-03-01)

The chemokine receptor CCR5: multi-faceted hook for HIV-1
per: Natacha Faivre, et al.
Publicat: (2024-01-01)

In Silico Identification of Cholesterol Binding Motifs in the Chemokine Receptor CCR3
per: Evan van Aalst, et al.
Publicat: (2021-07-01)

Structural basis of dimerization of chemokine receptors CCR5 and CXCR4
per: Daniele Di Marino, et al.
Publicat: (2023-10-01)

Chemokine receptor CCR3 is important for migration of mast cells in neurofibroma
per: Wei-Chun Tai, et al.
Publicat: (2010-12-01)