[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.

[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.

The pathogenesis of amyotrophic lateral sclerosis (ALS) remains obscure, but it is now clear that neuronal loss is not confined to the motor cortex, even in cases without dementia. A reliable method of assessing cortical involvement in vivo remains elusive. WAY100635 binds selectively to the 5-hydro...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Turner, M, Rabiner, E, Hammers, A, Al-Chalabi, A, Grasby, P, Shaw, C, Brooks, D, Leigh, P
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2005

Παρόμοια τεκμήρια

[C-11]-WAY100635 PET: A surrogate marker for MND?
ανά: Turner, M, κ.ά.
Έκδοση: (2003)

5-HT1A receptor binding in panic disorder; comparison with depressive disorder and healthy volunteers using PET and [11C]WAY-100635
ανά: Sargent, P, κ.ά.
Έκδοση: (2000)

Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-(11)C]WAY-100635.
ανά: Rabiner, E, κ.ά.
Έκδοση: (2000)

5-HT(1A) receptor binding in euthymic bipolar patients using positron emission tomography with [carbonyl-(11)C]WAY-100635.
ανά: Sargent, P, κ.ά.
Έκδοση: (2010)

Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635.
ανά: Bhagwagar, Z, κ.ά.
Έκδοση: (2004)

A database of [(11)C]WAY-100635 binding to 5-HT(1A) receptors in normal male volunteers: normative data and relationship to methodological, demographic, physiological, and behavioral variables.
ανά: Rabiner, E, κ.ά.
Έκδοση: (2002)

Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: Studies with [11C]flumazenil PET
ανά: Turner, M, κ.ά.
Έκδοση: (2005)

Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET.
ανά: Turner, M, κ.ά.
Έκδοση: (2005)

Automated Synthesis of 5-HT1A Receptors Antagonists 11C-WAY-100635
ανά: LI Hui-qiang1,2;ZHEN Zhi-fei1;ZHANG Wei-feng1;LIAO Shu-guang1;LI Hong-li3;XU Jun-ling1,2
Έκδοση: (2017-02-01)

Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.
ανά: Sargent, P, κ.ά.
Έκδοση: (2000)

Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs sporadic ALS.
ανά: Turner, M, κ.ά.
Έκδοση: (2007)

A database of [11C]WAY-100635 binding ins healthy volunteers: relationship to demographic, physiological and personality variables
ανά: Rabiner, E, κ.ά.
Έκδοση: (2001)

Can we measure 5-HT release with PET?
ανά: Grasby, P, κ.ά.
Έκδοση: (2003)

Lack of effect of a single dose of hydrocortisone on serotonin(1A) receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635.
ανά: Bhagwagar, Z, κ.ά.
Έκδοση: (2003)

Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET.
ανά: Turner, M, κ.ά.
Έκδοση: (2007)

Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis.
ανά: Turner, M, κ.ά.
Έκδοση: (2007)

Pindolol occupancy of 5-HT(1A) receptors measured in vivo using small animal positron emission tomography with carbon-11 labeled WAY 100635.
ανά: Hirani, E, κ.ά.
Έκδοση: (2000)

Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS.
ανά: Turner, M, κ.ά.
Έκδοση: (2005)

Effect of endogenous 5-HT on [C-11]MDL 100907 binding investigated in rat brain using PET
ανά: Hirani, E, κ.ά.
Έκδοση: (2003)

Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study.
ανά: Wicks, P, κ.ά.
Έκδοση: (2008)

Cortical localisation of neuropsychological impairment in amyotrophic lateral sclerosis (ALS): An [C-11] Flumazenil PET study
ανά: Wicks, P, κ.ά.
Έκδοση: (2005)

Mills' and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET.
ανά: Turner, M, κ.ά.
Έκδοση: (2005)

Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression?
ανά: Rabiner, E, κ.ά.
Έκδοση: (2004)

Simplified quantification of 5-HT2A receptors in the human brain with [11C]MDL 100,907 PET and non-invasive kinetic analyses.
ανά: Meyer, P, κ.ά.
Έκδοση: (2010)

Fenfluramine evokes 5-HT2A receptor-mediated responses but does not displace [11C]MDL 100907: small animal PET and gene expression studies.
ανά: Hirani, E, κ.ά.
Έκδοση: (2003)

Attenuation of preferential occupancy of 5-HT1A autoreceptors by pindolol in depressed patients: effect of SSRIs or an endophenotype of the depressed state?
ανά: Rabiner, E, κ.ά.
Έκδοση: (2002)

Low index-to-ring finger length ratio in sporadic ALS supports prenatally defined motor neuronal vulnerability.
ανά: Vivekananda, U, κ.ά.
Έκδοση: (2011)

In vivo study of cerebral microglial activation in MND using [C-11]-PK11195 PET
ανά: Turner, M, κ.ά.
Έκδοση: (2004)

Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB.
ανά: Selvaraj, S, κ.ά.
Έκδοση: (2011)

Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907.
ανά: Hinz, R, κ.ά.
Έκδοση: (2007)

beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy.
ανά: Rabiner, E, κ.ά.
Έκδοση: (2000)

Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [11C]raclopride PET study.
ανά: Montgomery, A, κ.ά.
Έκδοση: (2003)

Lipoprotein particle profiles mark familial and sporadic human longevity.
ανά: Bastiaan T Heijmans, κ.ά.
Έκδοση: (2006-12-01)

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
ανά: Paul Edison, κ.ά.
Έκδοση: (2008-12-01)

Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907.
ανά: Bhagwagar, Z, κ.ά.
Έκδοση: (2006)

Genetic screening in sporadic ALS and FTD
ανά: Turner, M, κ.ά.
Έκδοση: (2017)

Imaging: MRS/MRI/PET/SPECT: summary.
ανά: Leigh, P, κ.ά.
Έκδοση: (2002)

Human 5-HT transporter availability predicts amygdala reactivity in vivo.
ανά: Rhodes, R, κ.ά.
Έκδοση: (2007)

Evidence for co-localisation of neurokinin-1 and 5-HT1A receptors in pat forebrain
ανά: Hafizi, S, κ.ά.
Έκδοση: (2004)

Tyrosine-free amino acid mixture attenuates amphetamine-induced displacement of [11C]raclopride in striatum in vivo: a rat PET study.
ανά: Le Masurier, M, κ.ά.
Έκδοση: (2004)