[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.
The pathogenesis of amyotrophic lateral sclerosis (ALS) remains obscure, but it is now clear that neuronal loss is not confined to the motor cortex, even in cases without dementia. A reliable method of assessing cortical involvement in vivo remains elusive. WAY100635 binds selectively to the 5-hydro...
المؤلفون الرئيسيون: | Turner, M, Rabiner, E, Hammers, A, Al-Chalabi, A, Grasby, P, Shaw, C, Brooks, D, Leigh, P |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2005
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مواد مشابهة
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[C-11]-WAY100635 PET: A surrogate marker for MND?
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Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-(11)C]WAY-100635.
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Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635.
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