[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.

[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.

The pathogenesis of amyotrophic lateral sclerosis (ALS) remains obscure, but it is now clear that neuronal loss is not confined to the motor cortex, even in cases without dementia. A reliable method of assessing cortical involvement in vivo remains elusive. WAY100635 binds selectively to the 5-hydro...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Turner, M, Rabiner, E, Hammers, A, Al-Chalabi, A, Grasby, P, Shaw, C, Brooks, D, Leigh, P
Natura:	Journal article
Lingua:	English
Pubblicazione:	2005

Documenti analoghi

[C-11]-WAY100635 PET: A surrogate marker for MND?
di: Turner, M, et al.
Pubblicazione: (2003)

5-HT1A receptor binding in panic disorder; comparison with depressive disorder and healthy volunteers using PET and [11C]WAY-100635
di: Sargent, P, et al.
Pubblicazione: (2000)

Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-(11)C]WAY-100635.
di: Rabiner, E, et al.
Pubblicazione: (2000)

5-HT(1A) receptor binding in euthymic bipolar patients using positron emission tomography with [carbonyl-(11)C]WAY-100635.
di: Sargent, P, et al.
Pubblicazione: (2010)

Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635.
di: Bhagwagar, Z, et al.
Pubblicazione: (2004)

A database of [(11)C]WAY-100635 binding to 5-HT(1A) receptors in normal male volunteers: normative data and relationship to methodological, demographic, physiological, and behavioral variables.
di: Rabiner, E, et al.
Pubblicazione: (2002)

Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: Studies with [11C]flumazenil PET
di: Turner, M, et al.
Pubblicazione: (2005)

Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET.
di: Turner, M, et al.
Pubblicazione: (2005)

Automated Synthesis of 5-HT1A Receptors Antagonists 11C-WAY-100635
di: LI Hui-qiang1,2;ZHEN Zhi-fei1;ZHANG Wei-feng1;LIAO Shu-guang1;LI Hong-li3;XU Jun-ling1,2
Pubblicazione: (2017-02-01)

Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.
di: Sargent, P, et al.
Pubblicazione: (2000)

Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs sporadic ALS.
di: Turner, M, et al.
Pubblicazione: (2007)

A database of [11C]WAY-100635 binding ins healthy volunteers: relationship to demographic, physiological and personality variables
di: Rabiner, E, et al.
Pubblicazione: (2001)

Can we measure 5-HT release with PET?
di: Grasby, P, et al.
Pubblicazione: (2003)

Lack of effect of a single dose of hydrocortisone on serotonin(1A) receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635.
di: Bhagwagar, Z, et al.
Pubblicazione: (2003)

Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET.
di: Turner, M, et al.
Pubblicazione: (2007)

Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis.
di: Turner, M, et al.
Pubblicazione: (2007)

Pindolol occupancy of 5-HT(1A) receptors measured in vivo using small animal positron emission tomography with carbon-11 labeled WAY 100635.
di: Hirani, E, et al.
Pubblicazione: (2000)

Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS.
di: Turner, M, et al.
Pubblicazione: (2005)

Effect of endogenous 5-HT on [C-11]MDL 100907 binding investigated in rat brain using PET
di: Hirani, E, et al.
Pubblicazione: (2003)

Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study.
di: Wicks, P, et al.
Pubblicazione: (2008)

Cortical localisation of neuropsychological impairment in amyotrophic lateral sclerosis (ALS): An [C-11] Flumazenil PET study
di: Wicks, P, et al.
Pubblicazione: (2005)

Mills' and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET.
di: Turner, M, et al.
Pubblicazione: (2005)

Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression?
di: Rabiner, E, et al.
Pubblicazione: (2004)

Simplified quantification of 5-HT2A receptors in the human brain with [11C]MDL 100,907 PET and non-invasive kinetic analyses.
di: Meyer, P, et al.
Pubblicazione: (2010)

Fenfluramine evokes 5-HT2A receptor-mediated responses but does not displace [11C]MDL 100907: small animal PET and gene expression studies.
di: Hirani, E, et al.
Pubblicazione: (2003)

Attenuation of preferential occupancy of 5-HT1A autoreceptors by pindolol in depressed patients: effect of SSRIs or an endophenotype of the depressed state?
di: Rabiner, E, et al.
Pubblicazione: (2002)

Low index-to-ring finger length ratio in sporadic ALS supports prenatally defined motor neuronal vulnerability.
di: Vivekananda, U, et al.
Pubblicazione: (2011)

In vivo study of cerebral microglial activation in MND using [C-11]-PK11195 PET
di: Turner, M, et al.
Pubblicazione: (2004)

Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB.
di: Selvaraj, S, et al.
Pubblicazione: (2011)

Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907.
di: Hinz, R, et al.
Pubblicazione: (2007)

beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy.
di: Rabiner, E, et al.
Pubblicazione: (2000)

Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [11C]raclopride PET study.
di: Montgomery, A, et al.
Pubblicazione: (2003)

Lipoprotein particle profiles mark familial and sporadic human longevity.
di: Bastiaan T Heijmans, et al.
Pubblicazione: (2006-12-01)

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
di: Paul Edison, et al.
Pubblicazione: (2008-12-01)

Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907.
di: Bhagwagar, Z, et al.
Pubblicazione: (2006)

Genetic screening in sporadic ALS and FTD
di: Turner, M, et al.
Pubblicazione: (2017)

Imaging: MRS/MRI/PET/SPECT: summary.
di: Leigh, P, et al.
Pubblicazione: (2002)

Human 5-HT transporter availability predicts amygdala reactivity in vivo.
di: Rhodes, R, et al.
Pubblicazione: (2007)

Evidence for co-localisation of neurokinin-1 and 5-HT1A receptors in pat forebrain
di: Hafizi, S, et al.
Pubblicazione: (2004)

Tyrosine-free amino acid mixture attenuates amphetamine-induced displacement of [11C]raclopride in striatum in vivo: a rat PET study.
di: Le Masurier, M, et al.
Pubblicazione: (2004)