HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation.
The potential importance of HLA-C-restricted CD8+ cytotoxic T lymphocytes (CTL) in HIV infection remains undetermined. We studied the dominant HLA-Cw*03-restricted CTL response to YVDRFFKTL(296-304) (YL9), within the conserved major homology region (MHR) of the Gag protein, in 80 HLA-Cw*03-positive...
Main Authors: | Honeyborne, I, Codoñer, F, Leslie, A, Tudor-Williams, G, Luzzi, G, Ndung'u, T, Walker, B, Goulder, P, Prado, J |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
2010
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