Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.
The CD8+ T cell response to Epstein-Barr virus (EBV) is well characterized. Much less is known about the evolution of the CD4+ T cell response. Here we show that EBV stimulates a primary burst of effector CD4+ T cells and this is followed by a period of down-regulation. A small population of EBV-spe...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1797062914103836672 |
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| author | Amyes, E Hatton, C Montamat-Sicotte, D Gudgeon, N Rickinson, AB Mcmichael, A Callan, M |
| author_facet | Amyes, E Hatton, C Montamat-Sicotte, D Gudgeon, N Rickinson, AB Mcmichael, A Callan, M |
| author_sort | Amyes, E |
| collection | OXFORD |
| description | The CD8+ T cell response to Epstein-Barr virus (EBV) is well characterized. Much less is known about the evolution of the CD4+ T cell response. Here we show that EBV stimulates a primary burst of effector CD4+ T cells and this is followed by a period of down-regulation. A small population of EBV-specific effector CD4+ T cells survives during the lifelong persistent phase of infection. The EBV-specific effector CD4+ T cells accumulate within a CD27+ CD28+ differentiation compartment during primary infection and remain enriched within this compartment throughout the persistent phase of infection. Analysis of CD4+ T cell responses to individual epitopes from EBV latent and lytic cycle proteins confirms the observation that the majority of the effector cells express both CD27 and CD28, although CD4+ T cells specific for lytic cycle antigens have a greater tendency to express CD45RA than those specific for the latent antigens. In clear contrast, effector CD4+ T cells specific for cytomegalovirus (CMV) accumulate within the CD27- CD28+ and CD27- CD28- compartments. There are striking parallels in terms of the differentiation of CD8+ T cells specific for EBV and CMV. The results challenge current ideas on the definition of memory subsets. |
| first_indexed | 2024-03-06T20:52:21Z |
| format | Journal article |
| id | oxford-uuid:3804ffb5-3359-4afb-9e17-a78cffc1bf3c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:52:21Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:3804ffb5-3359-4afb-9e17-a78cffc1bf3c2022-03-26T13:47:30ZCharacterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3804ffb5-3359-4afb-9e17-a78cffc1bf3cEnglishSymplectic Elements at Oxford2003Amyes, EHatton, CMontamat-Sicotte, DGudgeon, NRickinson, ABMcmichael, ACallan, MThe CD8+ T cell response to Epstein-Barr virus (EBV) is well characterized. Much less is known about the evolution of the CD4+ T cell response. Here we show that EBV stimulates a primary burst of effector CD4+ T cells and this is followed by a period of down-regulation. A small population of EBV-specific effector CD4+ T cells survives during the lifelong persistent phase of infection. The EBV-specific effector CD4+ T cells accumulate within a CD27+ CD28+ differentiation compartment during primary infection and remain enriched within this compartment throughout the persistent phase of infection. Analysis of CD4+ T cell responses to individual epitopes from EBV latent and lytic cycle proteins confirms the observation that the majority of the effector cells express both CD27 and CD28, although CD4+ T cells specific for lytic cycle antigens have a greater tendency to express CD45RA than those specific for the latent antigens. In clear contrast, effector CD4+ T cells specific for cytomegalovirus (CMV) accumulate within the CD27- CD28+ and CD27- CD28- compartments. There are striking parallels in terms of the differentiation of CD8+ T cells specific for EBV and CMV. The results challenge current ideas on the definition of memory subsets. |
| spellingShingle | Amyes, E Hatton, C Montamat-Sicotte, D Gudgeon, N Rickinson, AB Mcmichael, A Callan, M Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. |
| title | Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. |
| title_full | Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. |
| title_fullStr | Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. |
| title_full_unstemmed | Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. |
| title_short | Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. |
| title_sort | characterization of the cd4 t cell response to epstein barr virus during primary and persistent infection |
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