Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility
DNA strands containing a triazole linkage flanked on its 3′-side by an aminoethylphenoxazine nucleobase analogue (G-clamp) have been prepared by solid-phase synthesis followed by CuAAC-mediated click oligonucleotide ligation. The stability of the doubly modified DNA duplexes and DNA-RNA hybrids is g...
Автори: | El-Sagheer, A, Brown, T |
---|---|
Формат: | Journal article |
Опубліковано: |
Royal Society of Chemistry
2014
|
Схожі ресурси
Схожі ресурси
-
Enhanced H-bonding and pi-stacking in DNA: a potent duplex-stabilizing and mismatch sensing nucleobase analogue
за авторством: Lou, C, та інші
Опубліковано: (2014) -
Molecular requirements of high-fidelity replication-competent DNA backbones for orthogonal chemical ligation.
за авторством: Shivalingam, A, та інші
Опубліковано: (2017) -
Assessing the biocompatibility of click-linked DNA in Escherichia coli.
за авторством: Sanzone, A, та інші
Опубліковано: (2012) -
RNAfitme: a webserver for modeling nucleobase and nucleoside residue conformation in fixed-backbone RNA structures
за авторством: Maciej Antczak, та інші
Опубліковано: (2018-08-01) -
Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli.
за авторством: El-Sagheer, A, та інші
Опубліковано: (2011)