Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility

Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility

DNA strands containing a triazole linkage flanked on its 3′-side by an aminoethylphenoxazine nucleobase analogue (G-clamp) have been prepared by solid-phase synthesis followed by CuAAC-mediated click oligonucleotide ligation. The stability of the doubly modified DNA duplexes and DNA-RNA hybrids is g...

书目详细资料
Main Authors:	El-Sagheer, A, Brown, T
格式:	Journal article
出版:	Royal Society of Chemistry 2014

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