Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility
DNA strands containing a triazole linkage flanked on its 3′-side by an aminoethylphenoxazine nucleobase analogue (G-clamp) have been prepared by solid-phase synthesis followed by CuAAC-mediated click oligonucleotide ligation. The stability of the doubly modified DNA duplexes and DNA-RNA hybrids is g...
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| פורמט: | Journal article |
| יצא לאור: |
Royal Society of Chemistry
2014
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