Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

Objective: FBXW7 encodes the substrate recognition component of a ubiquitin ligase that degrades targets such as Notch1, c-Jun, c-Myc and cyclin E. FBXW7 mutations occur in several tumour types, including colorectal cancers. The FBXW7 mutation spectrum in cancers is unusual. Some tumours have bialle...

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Bibliographic Details
Main Authors:	Davis, H, Lewis, A, Behrens, A, Tomlinson, I
Format:	Journal article
Language:	English
Published:	BMJ Publishing Group 2014

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. by Davis, H, Lewis, A, Behrens, A, Tomlinson, I

Published 2014

Journal article

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. by Davis, H, Lewis, A, Behrens, A, Tomlinson, I

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