Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.

Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.

AIMS/HYPOTHESIS: The aim of this study was to measure the heritability estimates for metabolic traits and the features of the insulin resistance syndrome in families with an increased genetic susceptibility to Type 2 diabetes. METHODS: A total of 811 non-diabetic relatives from 278 pedigrees of nort...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Mills, G, Avery, P, McCarthy, M, Hattersley, A, Levy, J, Hitman, G, Sampson, M, Walker, M
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2004

Antzeko izenburuak

Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes.
nork: Singh, R, et al.
Argitaratua: (2006)

Reduced beta cell function in offspring of mothers with young onset type 2 diabetes
nork: Singh, R, et al.
Argitaratua: (2005)

Common variation in the LMNA gene increases susceptibility to type 2 diabetes
nork: Owen, K, et al.
Argitaratua: (2006)

The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.
nork: Desai, M, et al.
Argitaratua: (2006)

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
nork: Groves, C, et al.
Argitaratua: (2003)

Susceptibility for latent autoimmune diabetes in adults (LADA) is determined by variation at the 1DDM2 (insulin-gene) locus in white Caucasian patients from UK repositories
nork: Desai, M, et al.
Argitaratua: (2005)

The heritability of premenstrual syndrome
nork: Jahanfar, Shayesteh, et al.
Argitaratua: (2011)

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
nork: Owen, K, et al.
Argitaratua: (2004)

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
nork: Zeggini, E, et al.
Argitaratua: (2004)

Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
nork: Freathy, R, et al.
Argitaratua: (2007)

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
nork: Frayling, T, et al.
Argitaratua: (2003)

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
nork: Frayling, T, et al.
Argitaratua: (2000)

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
nork: Huxtable, S, et al.
Argitaratua: (2000)

Type 2 diabetes and the human homolog of the rat insulin resistance gene, CD36: No linkage or association in Europeans
nork: McCarthy, M, et al.
Argitaratua: (1999)

Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.
nork: Zeggini, E, et al.
Argitaratua: (2005)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
nork: Gloyn, A, et al.
Argitaratua: (2003)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
nork: Gloyn, A, et al.
Argitaratua: (2003)

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
nork: Patel, S, et al.
Argitaratua: (2006)

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
nork: Wiltshire, S, et al.
Argitaratua: (2004)

Susceptibility effects of variation at the IDDM2 (Insulin-gene) locus in latent autoimmune diabetes in adults (LADA).
nork: Desai, M, et al.
Argitaratua: (2003)

Dissecting the heritable risk of breast cancer: from statistical methods to susceptibility genes
nork: Fanfani, V, et al.
Argitaratua: (2020)

Association of insulin gene VNTR polymorphism with polycystic ovary syndrome - Reply
nork: Bennett, S, et al.
Argitaratua: (1997)

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
nork: Zeggini, E, et al.
Argitaratua: (2005)

Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
nork: Edghill, E, et al.
Argitaratua: (2011)

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
nork: Liew, C, et al.
Argitaratua: (2004)

Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls.
nork: Chinnery, P, et al.
Argitaratua: (2007)

Beta-cell function improved by supplementing basal insulin secretion in mild diabetes.
nork: Turner, R, et al.
Argitaratua: (1976)

Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.
nork: Weedon, M, et al.
Argitaratua: (2003)

On negative heritability and negative estimates of heritability
nork: Steinsaltz, D, et al.
Argitaratua: (2020)

[Insulin secretion in non-insulin-dependent diabetes]
nork: Turner, R, et al.
Argitaratua: (1991)

Insulin secretion in non-insulin-dependent diabetes
nork: Turner, R, et al.
Argitaratua: (1991)

Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.
nork: Wiltshire, S, et al.
Argitaratua: (2006)

An increase in insulin sensitivity and basal beta-cell function in diabetic subjects treated with pioglitazone in a placebo-controlled randomized study.
nork: Wallace, T, et al.
Argitaratua: (2004)

Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries.
nork: Franks, S, et al.
Argitaratua: (2008)

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.
nork: Haddad, L, et al.
Argitaratua: (2002)

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
nork: Groves, C, et al.
Argitaratua: (2006)

The BDA Warren Type 2 Diabetes Sibpair Repository: Susceptibility regions identified by genome scan of 439 European families
nork: McCarthy, M, et al.
Argitaratua: (2000)

Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome.
nork: Waterworth, D, et al.
Argitaratua: (1997)

Finding the missing heritability of complex diseases.
nork: Manolio, T, et al.
Argitaratua: (2009)

Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome.
nork: Draper, N, et al.
Argitaratua: (2006)