Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease.

Eitemau Tebyg

• FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia.
  gan: Mead, A, et al.
  Cyhoeddwyd: (2007)
• Higher daunorubicin exposure benefits FLT3 mutated acute myeloid leukemia
  gan: Burnett, A, et al.
  Cyhoeddwyd: (2016)
• The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.
  gan: Gale, R, et al.
  Cyhoeddwyd: (2008)
• Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication.
  gan: Mead, A, et al.
  Cyhoeddwyd: (2008)
• SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia
  gan: Puissant, Alexandre, et al.
  Cyhoeddwyd: (2017)