DNA base damage recognition and processing
In living cells DNA base lesions are formed continuously as a consequence of normal metabolism and are also generated by a number of external factors. Simple base damages are repaired by base excision repair that is initiated by a damage specific DNA glycosylase, which removes the damaged base creat...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1797062964663025664 |
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| author | Dianov, G Allinson, S |
| author_facet | Dianov, G Allinson, S |
| author_sort | Dianov, G |
| collection | OXFORD |
| description | In living cells DNA base lesions are formed continuously as a consequence of normal metabolism and are also generated by a number of external factors. Simple base damages are repaired by base excision repair that is initiated by a damage specific DNA glycosylase, which removes the damaged base creating an abasic site (apurinic/apyrimidinic, AP site). AP endonuclease cleaves the phosphodiester bond 5′ to the AP site and then DNA polymerase β adds the first nucleotide to the 3′-end of the incised AP site and at the same time removes the 5′-sugar phosphate residue. DNA ligase completes the repair by sealing the DNA ends. These processes are directed and co-ordinated by multiple protein-protein interactions. This review focuses primarily on mammalian base excision repair, and in particular addresses the enzymology of the repair process and co-ordination of repair reactions. © 2005 Springer-Verlag Berlin Heidelberg. |
| first_indexed | 2024-03-06T20:53:04Z |
| format | Journal article |
| id | oxford-uuid:383e9963-092e-430f-9f7b-670783d38d86 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:53:04Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:383e9963-092e-430f-9f7b-670783d38d862022-03-26T13:48:55ZDNA base damage recognition and processingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:383e9963-092e-430f-9f7b-670783d38d86EnglishSymplectic Elements at Oxford2007Dianov, GAllinson, SIn living cells DNA base lesions are formed continuously as a consequence of normal metabolism and are also generated by a number of external factors. Simple base damages are repaired by base excision repair that is initiated by a damage specific DNA glycosylase, which removes the damaged base creating an abasic site (apurinic/apyrimidinic, AP site). AP endonuclease cleaves the phosphodiester bond 5′ to the AP site and then DNA polymerase β adds the first nucleotide to the 3′-end of the incised AP site and at the same time removes the 5′-sugar phosphate residue. DNA ligase completes the repair by sealing the DNA ends. These processes are directed and co-ordinated by multiple protein-protein interactions. This review focuses primarily on mammalian base excision repair, and in particular addresses the enzymology of the repair process and co-ordination of repair reactions. © 2005 Springer-Verlag Berlin Heidelberg. |
| spellingShingle | Dianov, G Allinson, S DNA base damage recognition and processing |
| title | DNA base damage recognition and processing |
| title_full | DNA base damage recognition and processing |
| title_fullStr | DNA base damage recognition and processing |
| title_full_unstemmed | DNA base damage recognition and processing |
| title_short | DNA base damage recognition and processing |
| title_sort | dna base damage recognition and processing |
| work_keys_str_mv | AT dianovg dnabasedamagerecognitionandprocessing AT allinsons dnabasedamagerecognitionandprocessing |