Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells

Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells

We analyzed the effect of transcribed noncoding RNA centromeric satellites on chromosome segregation in normal human and murine stem and fibrosarcoma cells. The overexpression of different centromeric alphoid DNAs in all cell lines induced a marked increase in chromosome mis-segregation in anaphase....

Full description

Bibliographic Details
Main Authors:	Chan, D, Moralli, D, Khoja, S, Monaco, Z
Format:	Journal article
Language:	English
Published:	Hindawi 2017

Similar Items

Human artificial chromosomes containing chromosome 17 alphoid DNA maintain an active centromere in murine cells but are not stable.
by: Alazami, A, et al.
Published: (2004)

Human artificial chromosomes maintained in human embryonic stem and neuronal cells
by: Moralli, D, et al.
Published: (2013)

Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells.
by: Mandegar, M, et al.
Published: (2011)

Development of Artificial Chromosomes in Human Embryonic Stem Cells
by: Mandegar, M, et al.
Published: (2010)

HAC stability in murine cells is influenced by nuclear localization and chromatin organization
by: Moralli, D, et al.
Published: (2009)

An improved technique for chromosomal analysis of human ES and iPS cells.
by: Moralli, D, et al.
Published: (2011)

An Improved Technique for Chromosomal Analysis of Human ES and iPS Cells
by: Moralli, D, et al.
Published: (2011)

Analysis of the centromeric region of the human Y chromosome
by: Cooper, K, et al.
Published: (1992)

Genome-wide analysis of long noncoding RNA stability.
by: Clark, M, et al.
Published: (2012)

The protective role of MC1R in chromosome stability and centromeric integrity in melanocytes
by: Li, X, et al.
Published: (2021)

Mapping studies of the centromeric region of the human Y chromosome
by: Williams, G, et al.
Published: (1998)

Efficiency of de novo centromere formation in human artificial chromosomes.
by: Mejía, J, et al.
Published: (2002)

Progress in artificial chromosome technology.
by: Monaco, Z, et al.
Published: (2006)

Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells
by: Almada, Albert Ernesto, et al.
Published: (2013)

[Modifications of centromeric cohesin for meiosis specific chromosome segregation].
by: Akiyoshi, B, et al.
Published: (2004)

Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation
by: Unhavaithaya, Yingdee, et al.
Published: (2014)

A Circuitous Route to Noncoding RNA
by: Sharp, Phillip A., et al.
Published: (2015)

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity
by: Lu, Xinyi, et al.
Published: (2016)

Functional identification of the Plasmodium centromere and generation of a Plasmodium artificial chromosome.
by: Iwanaga, S, et al.
Published: (2010)

A novel human artificial chromosome gene expression system using herpes simplex virus type 1 vectors.
by: Moralli, D, et al.
Published: (2006)

Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes.
by: Chodroff, R, et al.
Published: (2010)

Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2.
by: Fakis, G, et al.
Published: (2000)

Specialized replication mechanisms maintain genome stability at human centromeres
by: Scelfo, A, et al.
Published: (2024)

Significant evidence for a schizophrenia susceptibility locus in the centromeric region of human chromosome
by: Shaw, S, et al.
Published: (2001)

Turnover and function of noncoding RNA polymerase II transcripts.
by: Dye, M, et al.
Published: (2006)

Localization of DNA sequences required for human centromere function through an analysis of rearranged Y chromosomes.
by: Tyler-Smith, C, et al.
Published: (1993)

Alpha-satellite RNA transcripts are repressed by centromere–nucleolus associations
by: Bury, Leah, et al.
Published: (2021)

HSV-1 delivery of artificial chromosomes to human cells
by: Moralli, D, et al.
Published: (2004)

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.
by: Ling, H, et al.
Published: (2013)

Multigene human artificial chromosome vector delivery with herpes simplex virus 1 amplicons
by: Chan, DYL, et al.
Published: (2020)

Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres
by: Guin, Krishnendu, et al.
Published: (2020)

Discovery of an Unconventional Centromere in Budding Yeast Redefines Evolution of Point Centromeres.
by: Kobayashi, N, et al.
Published: (2015)

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling
by: Micheletti, Rudi, et al.
Published: (2018)

Transcriptional interference and gene orientation in yeast: noncoding RNA connections.
by: Gullerova, M, et al.
Published: (2010)

Isozyme expression and gene-centromere distances in diploid and triploid hybrid catfish
by: Liu, Q, et al.
Published: (1996)

ParABS systems of the four replicons of Burkholderia cenocepacia: new chromosome centromeres confer partition specificity.
by: Dubarry, N, et al.
Published: (2006)

Rapid turnover of long noncoding RNAs and the evolution of gene expression
by: Kutter, C, et al.
Published: (2012)

Mechanisms for the propagation and recognition of human centromeres
by: McKinley, Kara Lavidge
Published: (2016)

Disruption of a Large Intergenic Noncoding RNA in Subjects with Neurodevelopmental Disabilities
by: Kellis, Manolis, et al.
Published: (2014)

The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis
by: Ng, Shi-Yan, et al.
Published: (2016)