Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers.
We introduce the notion of cell division-induced activity and show that the cell division generates extensile forces and drives dynamical patterns in cell assemblies. Extending the hydrodynamic models of lyotropic active nematics we describe turbulent-like velocity fields that are generated by the c...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2015
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| _version_ | 1797063015558807552 |
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| author | Doostmohammadi, A Thampi, S Saw, T Lim, C Ladoux, B Yeomans, J |
| author_facet | Doostmohammadi, A Thampi, S Saw, T Lim, C Ladoux, B Yeomans, J |
| author_sort | Doostmohammadi, A |
| collection | OXFORD |
| description | We introduce the notion of cell division-induced activity and show that the cell division generates extensile forces and drives dynamical patterns in cell assemblies. Extending the hydrodynamic models of lyotropic active nematics we describe turbulent-like velocity fields that are generated by the cell division in a confluent monolayer of cells. We show that the experimentally measured flow field of dividing Madin-Darby Canine Kidney (MDCK) cells is reproduced by our modeling approach. Division-induced activity acts together with intrinsic activity of the cells in extensile and contractile cell assemblies to change the flow and director patterns and the density of topological defects. Finally we model the evolution of the boundary of a cellular colony and compare the fingering instabilities induced by cell division to experimental observations on the expansion of MDCK cell cultures. |
| first_indexed | 2024-03-06T20:53:48Z |
| format | Journal article |
| id | oxford-uuid:38807541-9d64-43d1-837a-5430140526a0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:53:48Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:38807541-9d64-43d1-837a-5430140526a02022-03-26T13:50:23ZCelebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:38807541-9d64-43d1-837a-5430140526a0EnglishSymplectic Elements at OxfordRoyal Society of Chemistry2015Doostmohammadi, AThampi, SSaw, TLim, CLadoux, BYeomans, JWe introduce the notion of cell division-induced activity and show that the cell division generates extensile forces and drives dynamical patterns in cell assemblies. Extending the hydrodynamic models of lyotropic active nematics we describe turbulent-like velocity fields that are generated by the cell division in a confluent monolayer of cells. We show that the experimentally measured flow field of dividing Madin-Darby Canine Kidney (MDCK) cells is reproduced by our modeling approach. Division-induced activity acts together with intrinsic activity of the cells in extensile and contractile cell assemblies to change the flow and director patterns and the density of topological defects. Finally we model the evolution of the boundary of a cellular colony and compare the fingering instabilities induced by cell division to experimental observations on the expansion of MDCK cell cultures. |
| spellingShingle | Doostmohammadi, A Thampi, S Saw, T Lim, C Ladoux, B Yeomans, J Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers. |
| title | Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers. |
| title_full | Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers. |
| title_fullStr | Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers. |
| title_full_unstemmed | Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers. |
| title_short | Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers. |
| title_sort | celebrating soft matter s 10th anniversary cell division a source of active stress in cellular monolayers |
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