Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues
Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid using a bicyclic lactam as a synthetic template; diastereocontrolled modification of the pyrrolidine ring using a sequential conjugate addition-substitution strategy permits access to several kain...
| Հիմնական հեղինակներ: | , , , |
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| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
2000
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| _version_ | 1826267414465085440 |
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| author | Dyer, J King, A Keeling, S Moloney, M |
| author_facet | Dyer, J King, A Keeling, S Moloney, M |
| author_sort | Dyer, J |
| collection | OXFORD |
| description | Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid using a bicyclic lactam as a synthetic template; diastereocontrolled modification of the pyrrolidine ring using a sequential conjugate addition-substitution strategy permits access to several kainoid analogues in a versatile strategy. The pyrrolidinone ring conformation appears to be controllable by the nature of remote substituents on the heterocyclic ring. © The Royal Society of Chemistry 2000. |
| first_indexed | 2024-03-06T20:53:50Z |
| format | Journal article |
| id | oxford-uuid:38831d00-bc92-4a4c-81fa-c2040fa5dee5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:53:50Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:38831d00-bc92-4a4c-81fa-c2040fa5dee52022-03-26T13:50:27ZPyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analoguesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:38831d00-bc92-4a4c-81fa-c2040fa5dee5EnglishSymplectic Elements at Oxford2000Dyer, JKing, AKeeling, SMoloney, MNovel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid using a bicyclic lactam as a synthetic template; diastereocontrolled modification of the pyrrolidine ring using a sequential conjugate addition-substitution strategy permits access to several kainoid analogues in a versatile strategy. The pyrrolidinone ring conformation appears to be controllable by the nature of remote substituents on the heterocyclic ring. © The Royal Society of Chemistry 2000. |
| spellingShingle | Dyer, J King, A Keeling, S Moloney, M Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues |
| title | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues |
| title_full | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues |
| title_fullStr | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues |
| title_full_unstemmed | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues |
| title_short | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues |
| title_sort | pyrrolidinones derived from s pyroglutamic acid part 2 conformationally constrained kainoid analogues |
| work_keys_str_mv | AT dyerj pyrrolidinonesderivedfromspyroglutamicacidpart2conformationallyconstrainedkainoidanalogues AT kinga pyrrolidinonesderivedfromspyroglutamicacidpart2conformationallyconstrainedkainoidanalogues AT keelings pyrrolidinonesderivedfromspyroglutamicacidpart2conformationallyconstrainedkainoidanalogues AT moloneym pyrrolidinonesderivedfromspyroglutamicacidpart2conformationallyconstrainedkainoidanalogues |