Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues

Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid using a bicyclic lactam as a synthetic template; diastereocontrolled modification of the pyrrolidine ring using a sequential conjugate addition-substitution strategy permits access to several kain...

Bibliografiset tiedot
Päätekijät:	Dyer, J, King, A, Keeling, S, Moloney, M
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2000

Samankaltaisia teoksia

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 1. Conformationally constrained glutamate
Tekijä: Bailey, J, et al.
Julkaistu: (2000)

Pyrrolidinones derived from (S)-pyroglutamic acid: penmacric acid and analogues.
Tekijä: Anwar, M, et al.
Julkaistu: (2003)

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinones
Tekijä: Chan, P, et al.
Julkaistu: (2001)

Functionalised pyrrolidinones derived from (S)-pyroglutamic acid
Tekijä: Beard, M, et al.
Julkaistu: (1996)

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. alpha,beta-diaminopyrrolidinones
Tekijä: Chan, P, et al.
Julkaistu: (2001)

Functionalised pyrrolidinones derived from (S)-pyroglutamic acid by cycloaddition reactions
Tekijä: Bailey, J, et al.
Julkaistu: (1997)

Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.
Tekijä: Bentz, E, et al.
Julkaistu: (2005)

Azasugar analogues: conformationally restricted vicinal diamine derived from (S)-(-)-pyroglutamic acid
Tekijä: Chan, P, et al.
Julkaistu: (1999)

Novel peptidomimetic structures: enantioselective synthesis of conformationally constrained lysine, ornithine and alanine analogues from pyroglutamic acid
Tekijä: Goswami, R, et al.
Julkaistu: (1999)

Direct versatile route to conformationally constrained glutamate analogues
Tekijä: Dyer, J, et al.
Julkaistu: (1998)

Functionalised pyrrolidinones by conjugate addition of stabilised enolates and reformatsky reagents
Tekijä: Dyer, J, et al.
Julkaistu: (1996)

ENANTIOSELECTIVE KAINOID SYNTHESIS BY COBALT-MEDIATED CYCLIZATION OF AN AMINO-ACID DERIVATIVE
Tekijä: Baldwin, J, et al.
Julkaistu: (1990)

Stereocontrolled spirocyclic bislactams derived from pyroglutamic acid
Tekijä: Hill, T, et al.
Julkaistu: (2006)

Spirocyclic systems derived from pyroglutamic acid.
Tekijä: Cowley, A, et al.
Julkaistu: (2011)

ENANTIOSELECTIVE SYNTHESIS OF KAINOID ANALOGS BY COBALT-MEDIATED CYCLIZATIONS
Tekijä: Baldwin, J, et al.
Julkaistu: (1991)

Mimics of pramanicin derived from pyroglutamic acid and their antibacterial activity.
Tekijä: Tan, S, et al.
Julkaistu: (2017)

Highly functionalised pyroglutamates by intramolecular aldol reactions: Towards the pyroglutamate skeleton of oxazolomycin
Tekijä: Andrews, MD, et al.
Julkaistu: (1996)

Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity
Tekijä: Anwar, M, et al.
Julkaistu: (2010)

Synthesis of mimics of pramanicin from pyroglutamic acid and their antibacterial activity.
Tekijä: Tan, S, et al.
Julkaistu: (2015)

(L)-PYROGLUTAMIC ACID AS A CHIRAL STARTING MATERIAL FOR ASYMMETRIC-SYNTHESIS
Tekijä: Baldwin, J, et al.
Julkaistu: (1991)

Conjugate addition of nitrogen nucleophiles to an unsaturated pyrrolidinone.
Tekijä: Chan, P, et al.
Julkaistu: (1998)

Equilibration in bicyclic pyroglutamates by ring opening-reclosure
Tekijä: Moloney, M, et al.
Julkaistu: (2008)

A CONCISE APPROACH TO FUNCTIONALIZED, HOMOCHIRAL PYRROLIDINONES
Tekijä: Bamford, M, et al.
Julkaistu: (1995)

AMINO-ACID SYNTHESIS USING (L)-PYROGLUTAMIC ACID AS A CHIRAL STARTING MATERIAL
Tekijä: Baldwin, J, et al.
Julkaistu: (1989)

Intramolecular aldol ring closures of cysteine derivatives leading to densely functionalised pyroglutamates
Tekijä: Almahli, H, et al.
Julkaistu: (2019)

Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues
Tekijä: Likun Ai, et al.
Julkaistu: (2022-12-01)

Conjugate addition of nitrogen nucleophiles to an alpha,beta-unsaturated pyrrolidinone
Tekijä: Chan, P, et al.
Julkaistu: (1997)

Synthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteine
Tekijä: Bagum, H, et al.
Julkaistu: (2019)

Aryldiazirine-modified pyroglutamates: Photoaffinity labels for glutamate
Tekijä: Bentz, E, et al.
Julkaistu: (2006)

Molecular Dynamics Simulation Reveal the Structure–Activity Relationships of Kainoid Synthases
Tekijä: Zeyu Fan, et al.
Julkaistu: (2024-07-01)

Diastereoselective intramolecular aldol ring closures of threonine derivatives leading to densely functionalised pyroglutamates related to oxazolomycin
Tekijä: Heaviside, E, et al.
Julkaistu: (2014)

Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates
Tekijä: Josa-Culleré, L, et al.
Julkaistu: (2018)

Synthetic access to 3,4-disubstituted pyroglutamates from tetramate derivatives from serine, allo-threonine and cysteine
Tekijä: Bagum, H, et al.
Julkaistu: (2019)

Synthesis of the pyrrolidinone core of oxazolomycin A
Tekijä: O'Riordan, TJC
Julkaistu: (2009)

Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin
Tekijä: Angelov, P, et al.
Julkaistu: (2012)

Stereocontrolled syntheses of kainoid amino acids from 7-azabicyclo[2.2.1]heptadienes using tandem radical addition-homoallylic radical rearrangement.
Tekijä: Hodgson, D, et al.
Julkaistu: (2005)

Divergent synthesis and antitumour activity of novel conformationally constrained (−)-muricatacin analogues
Tekijä: Stanisavljević Slađana M., et al.
Julkaistu: (2023-01-01)

Synthesis of the pyrrolidinone core of KSM-2690 B.
Tekijä: Donohoe, T, et al.
Julkaistu: (2007)

Synthesis of the pyrrolidinone core of KSM-2690 B
Tekijä: Donohoe, T, et al.
Julkaistu: (2007)

Design, synthesis, and herbicidal evaluation of pyrrolidinone-containing 2‑phenylpyridine derivatives as novel protoporphyrinogen oxidase inhibitors
Tekijä: Zhang, Meng, et al.
Julkaistu: (2024)