Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues
Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid using a bicyclic lactam as a synthetic template; diastereocontrolled modification of the pyrrolidine ring using a sequential conjugate addition-substitution strategy permits access to several kain...
Prif Awduron: | , , , |
---|---|
Fformat: | Journal article |
Iaith: | English |
Cyhoeddwyd: |
2000
|