Design principles of biochemical oscillators.
Cellular rhythms are generated by complex interactions among genes, proteins and metabolites. They are used to control every aspect of cell physiology, from signalling, motility and development to growth, division and death. We consider specific examples of oscillatory processes and discuss four gen...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2008
|
| _version_ | 1797063024183345152 |
|---|---|
| author | Novák, B Tyson, J |
| author_facet | Novák, B Tyson, J |
| author_sort | Novák, B |
| collection | OXFORD |
| description | Cellular rhythms are generated by complex interactions among genes, proteins and metabolites. They are used to control every aspect of cell physiology, from signalling, motility and development to growth, division and death. We consider specific examples of oscillatory processes and discuss four general requirements for biochemical oscillations: negative feedback, time delay, sufficient 'nonlinearity' of the reaction kinetics and proper balancing of the timescales of opposing chemical reactions. Positive feedback is one mechanism to delay the negative-feedback signal. Biological oscillators can be classified according to the topology of the positive- and negative-feedback loops in the underlying regulatory mechanism. |
| first_indexed | 2024-03-06T20:53:56Z |
| format | Journal article |
| id | oxford-uuid:388a8d40-b451-42b5-84f3-5679897dd51f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:53:56Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:388a8d40-b451-42b5-84f3-5679897dd51f2022-03-26T13:50:37ZDesign principles of biochemical oscillators.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:388a8d40-b451-42b5-84f3-5679897dd51fEnglishSymplectic Elements at Oxford2008Novák, BTyson, JCellular rhythms are generated by complex interactions among genes, proteins and metabolites. They are used to control every aspect of cell physiology, from signalling, motility and development to growth, division and death. We consider specific examples of oscillatory processes and discuss four general requirements for biochemical oscillations: negative feedback, time delay, sufficient 'nonlinearity' of the reaction kinetics and proper balancing of the timescales of opposing chemical reactions. Positive feedback is one mechanism to delay the negative-feedback signal. Biological oscillators can be classified according to the topology of the positive- and negative-feedback loops in the underlying regulatory mechanism. |
| spellingShingle | Novák, B Tyson, J Design principles of biochemical oscillators. |
| title | Design principles of biochemical oscillators. |
| title_full | Design principles of biochemical oscillators. |
| title_fullStr | Design principles of biochemical oscillators. |
| title_full_unstemmed | Design principles of biochemical oscillators. |
| title_short | Design principles of biochemical oscillators. |
| title_sort | design principles of biochemical oscillators |
| work_keys_str_mv | AT novakb designprinciplesofbiochemicaloscillators AT tysonj designprinciplesofbiochemicaloscillators |