Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study.
BACKGROUND: While the excess mortality associated with a diagnosis of angina, myocardial infarction in middle-aged individuals is well established, there is little available evidence on the natural history of angina in population-based studies of older people. DESIGN: We conducted a 5-year follow-up...
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| Fformat: | Journal article |
| Iaith: | English |
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2007
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| _version_ | 1826267425155317760 |
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| author | Clarke, R Shipley, M Breeze, E Collins, R Marmot, M Halsey, J Fletcher, A Hemingway, H |
| author_facet | Clarke, R Shipley, M Breeze, E Collins, R Marmot, M Halsey, J Fletcher, A Hemingway, H |
| author_sort | Clarke, R |
| collection | OXFORD |
| description | BACKGROUND: While the excess mortality associated with a diagnosis of angina, myocardial infarction in middle-aged individuals is well established, there is little available evidence on the natural history of angina in population-based studies of older people. DESIGN: We conducted a 5-year follow-up of 6655 older men aged 67-90 years (mean age 77 years) who participated in the Whitehall Study of London Civil Servants. METHODS: Survival was examined in relation to a diagnosis of angina or myocardial infarction and to angina symptoms in a population-based study of older men living in the United Kingdom in the late 1990s. RESULTS: Compared with men without a diagnosis of myocardial ischaemia (n=5219), a diagnosis of angina alone (n=617), myocardial infarction alone (n=421) or both (n=398) were associated with about a threefold, fourfold and sixfold higher risk of death from coronary heart disease, respectively. Median expectation of life at age 70 years was reduced by about 2, 5 and 6 years for those with angina, myocardial infarction, or both, respectively. Current symptoms of angina among those without previously diagnosed angina, was associated with a 2-fold higher risk of coronary heart disease mortality than those without either diagnosis or symptoms. CONCLUSIONS: Both angina symptoms and diagnosis have a significant adverse effect on survival among men aged 70-90 years highlighting the importance of diagnosis and appropriate treatment of angina in old age. |
| first_indexed | 2024-03-06T20:54:00Z |
| format | Journal article |
| id | oxford-uuid:388fc74f-d4fb-423d-af34-36dc193dd8ca |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:54:00Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:388fc74f-d4fb-423d-af34-36dc193dd8ca2022-03-26T13:50:53ZSurvival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:388fc74f-d4fb-423d-af34-36dc193dd8caEnglishSymplectic Elements at Oxford2007Clarke, RShipley, MBreeze, ECollins, RMarmot, MHalsey, JFletcher, AHemingway, HBACKGROUND: While the excess mortality associated with a diagnosis of angina, myocardial infarction in middle-aged individuals is well established, there is little available evidence on the natural history of angina in population-based studies of older people. DESIGN: We conducted a 5-year follow-up of 6655 older men aged 67-90 years (mean age 77 years) who participated in the Whitehall Study of London Civil Servants. METHODS: Survival was examined in relation to a diagnosis of angina or myocardial infarction and to angina symptoms in a population-based study of older men living in the United Kingdom in the late 1990s. RESULTS: Compared with men without a diagnosis of myocardial ischaemia (n=5219), a diagnosis of angina alone (n=617), myocardial infarction alone (n=421) or both (n=398) were associated with about a threefold, fourfold and sixfold higher risk of death from coronary heart disease, respectively. Median expectation of life at age 70 years was reduced by about 2, 5 and 6 years for those with angina, myocardial infarction, or both, respectively. Current symptoms of angina among those without previously diagnosed angina, was associated with a 2-fold higher risk of coronary heart disease mortality than those without either diagnosis or symptoms. CONCLUSIONS: Both angina symptoms and diagnosis have a significant adverse effect on survival among men aged 70-90 years highlighting the importance of diagnosis and appropriate treatment of angina in old age. |
| spellingShingle | Clarke, R Shipley, M Breeze, E Collins, R Marmot, M Halsey, J Fletcher, A Hemingway, H Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study. |
| title | Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study. |
| title_full | Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study. |
| title_fullStr | Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study. |
| title_full_unstemmed | Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study. |
| title_short | Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study. |
| title_sort | survival in relation to angina symptoms and diagnosis among men aged 70 90 years the whitehall study |
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