Regulatory T cells for tolerance
Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full s...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2017
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| _version_ | 1797063032660033536 |
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| author | Kawai, K Uchiyama, M Hester, J Wood, K Issa, F |
| author_facet | Kawai, K Uchiyama, M Hester, J Wood, K Issa, F |
| author_sort | Kawai, K |
| collection | OXFORD |
| description | Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing. Initial safety and efficacy data are being reported, with trials assessing a number of different strategies for the introduction of Treg therapy. It is now more crucial than ever to elucidate further the function and behaviour of Tregs in vivo and ensure safe delivery. This review will discuss the current state of the art and future directions in Treg therapy. |
| first_indexed | 2024-03-06T20:54:04Z |
| format | Journal article |
| id | oxford-uuid:3892a760-fc2b-49cf-82a4-2c1b3e2b865d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:54:04Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:3892a760-fc2b-49cf-82a4-2c1b3e2b865d2022-03-26T13:50:49ZRegulatory T cells for toleranceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3892a760-fc2b-49cf-82a4-2c1b3e2b865dEnglishSymplectic Elements at OxfordElsevier2017Kawai, KUchiyama, MHester, JWood, KIssa, FRegulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing. Initial safety and efficacy data are being reported, with trials assessing a number of different strategies for the introduction of Treg therapy. It is now more crucial than ever to elucidate further the function and behaviour of Tregs in vivo and ensure safe delivery. This review will discuss the current state of the art and future directions in Treg therapy. |
| spellingShingle | Kawai, K Uchiyama, M Hester, J Wood, K Issa, F Regulatory T cells for tolerance |
| title | Regulatory T cells for tolerance |
| title_full | Regulatory T cells for tolerance |
| title_fullStr | Regulatory T cells for tolerance |
| title_full_unstemmed | Regulatory T cells for tolerance |
| title_short | Regulatory T cells for tolerance |
| title_sort | regulatory t cells for tolerance |
| work_keys_str_mv | AT kawaik regulatorytcellsfortolerance AT uchiyamam regulatorytcellsfortolerance AT hesterj regulatorytcellsfortolerance AT woodk regulatorytcellsfortolerance AT issaf regulatorytcellsfortolerance |