Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Abstract The SARS-CoV-2 coronavirus (CoV) causes COVID-19, a current global pandemic. SARS-CoV-2 belongs to an order of Nidovirales with very large RNA genomes. It is proposed that the fidelity of CoV genome replication is aided by an RNA nuclease complex, formed of non-structural proteins 14 and 10...

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Bibliografiska uppgifter
Huvudupphovsmän: Baddock, H, Brolih, S, Yosaatmadja, Y, Ratnaweera, M, Bielinski, M, Swift, L, Cruz-Migoni, A, Morris, G, Schofield, C, Gileadi, O, McHugh, P
Materialtyp: Journal article
Språk:English
Publicerad: Cold Spring Harbor Laboratory 2020

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