Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection.

BACKGROUND and AIMS: Cytotoxic T cells have been suggested to be responsible for lysis of hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency, kinetics, phenotype, and capacity for clonal expansion of circulating HBV-specific CD8 cells were analyzed directly in...

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Bibliographic Details
Main Authors: Maini, M, Boni, C, Ogg, G, King, A, Reignat, S, Lee, C, Larrubia, JR, Webster, G, Mcmichael, A, Ferrari, C, Williams, R, Vergani, D, Bertoletti, A
Format: Journal article
Language:English
Published: 1999